Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients

Statin Therapy as Primary Prevention in Exercising Adults: Best Evidence for Avoiding Myalgia

“…67 Observational evidence from a meta-analysis has associated the 2. 68 The best prospective cohort study suggests that vitamin D repletion can improve symptoms in 88% of statin-intolerant patients at 6 months. 69 No RCTs are available.…”

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

“…We can find definitions like: statin-associated myalgia/myopathy, statin-induced myalgia/myopathy or statin-related myalgia/myopathy (or muscle symptoms (SAMS)) [7][8][9]. The most recent statement of the European Atherosclerosis Society (EAS) has focused on SAMS, and avoided the use of the term 'statin intolerance', as it is not specific for muscle symptoms [10].…”

Lipids, blood pressure and kidney update 2014

“…Another factor potentially susceptible for involvement in statin-induced myopathy is the deficiency of vitamin D levels [62]. Indeed, a systematic review and meta-analysis of seven randomized controlled trials (n = 2420 patients) showed that low vitamin D levels are associated with myalgia in statin users [63]. Recent cross-sectional study on 5907 participants ≥40 years old proved that statin users with 25(OH)D <15 ng/mL had 1.9 times higher odds of myopathy compared to nonstatin users [64].…”