Analysis of volatile organic compounds in rats with dopaminergic lesion: Possible application for early detection of Parkinson’s disease

Khatib, Soliman; Finberg, J. P. M.; Artoul, Fadi; Lavner, Yizhar; Mahmood, Saeed; Tisch, Ulrike; Haick, Hossam; Aluf, Yuval; Vaya, Jacob

doi:10.1016/j.neuint.2014.06.016

Cited by 18 publications

(25 citation statements)

References 50 publications

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“…Another utility would be the early detection of hand tremors, so that patients can get early treatments for these diseases. Recent studies show that early detection of PD may help in selecting the appropriate treatment [15]. Finally, this application could also be useful for monitoring the individual responses to therapies.…”

Section: Introductionmentioning

confidence: 99%

A smartphone-based system for detecting hand tremors in unconstrained environments

García‐Magariño

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Plaza

et al. 2016

Pers Ubiquit Comput

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The detection of tremors can be crucial for the early diagnosis and proper treatment of some disorders such as Parkinson's disease. A smartphonebased application has been developed for detecting hand tremors. This application runs in background and distinguishes hand tremors from common daily activities. This application can facilitate the continuous monitoring of patients or the early detection of this symptom. The evaluation analyzes 1770 accelerometer samples with cross-validation for assessing the ability of the system for processing unknown data, obtaining a sensitivity of 95.8% and a specificity of 99.5%. It also analyzes continuous data for some volunteers for several days, which corroborated its high performance.

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Section: Introductionmentioning

confidence: 99%

A smartphone-based system for detecting hand tremors in unconstrained environments

García‐Magariño

Medrano

Plaza

et al. 2016

Pers Ubiquit Comput

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“…[ 60 ] In another study, 1 mL venous blood withdrawn with a syringe from rats was stored in sterile vials at 4 °C until analysis; 200 µL of blood was transferred into a GC‐MS vial where 5 µL toluene‐d8 was added as an internal standard from a solution of 10 ppm in methanol, and the samples were then injected into the GS‐MS using the SPME methodology. [ 56 ]…”

Section: Voc Samples Collectionmentioning

confidence: 99%

“…Brain of mice with lesioned noradrenergic neurons in brain and periphery was removed and the striatum dissected on ice and stored at –70 °C until analysis; for VOCs extraction by SPME, the striatum was weighed, PBS was added at 1:10 (w/v), the mixture was homogenized briefly on ice, and 200 µL of the homogenate was transferred into a GC‐MS vial where 5 µL toluene‐d8 was added as internal standard. [ 56 ]…”

Section: Voc Samples Collectionmentioning

confidence: 99%

“…Parkinson disease induced in rats was studied by analyzing breath, blood, and brain samples, and comparing the results with unaffected control rats. Six compounds were suggested as possible volatile biomarkers for Parkinson disease in the breath (Table 6—Section A), [ 29 ] three compounds in the blood (Table 6—Section B), [ 56 ] and five compounds in the brain (Table 6— Section C). [ 56 ] Among them, only the alcohol 1‐octen‐3‐ol was identified in two biological samples, namely blood and brain, however it presented an increased level in blood but decreased in the brain.…”

Section: Analytical Studiesmentioning

confidence: 99%

“…As a matter of fact, all suggested biomarkers found in the brain decreased as compared with their levels in the control samples. [ 56 ]…”

Section: Analytical Studiesmentioning

confidence: 99%

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Review on Volatolomic Studies as a Frontier Approach in Animal Research

et al. 2021

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This paper presents a comprehensive review of the research studies in volatolomics performed on animals so far. At first, the procedures proposed for the collection, preconcentration, and storing of the volatile organic compounds emitted by various biological samples of different animals are presented and discussed. Next, the results obtained in the analysis of the collected volatile samples with analytical equipment are shown. The possible volatile biomarkers identified for various diseases are highlighted for different types of diseases, animal species, and biological samples analyzed. The chemical classes of these compounds, as well as the biomarkers found in a higher number of animal diseases, are indicated, and their possible origin is analyzed. The studies that dealt with the diagnosis of various diseases from sample measurement with electronic nose systems are also presented and discussed. The paper ends with a final remark regarding the necessity of optimization and standardization of sample collection and analysis procedures for obtaining meaningful results.

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Identification of volatile biomarkers of Giardia duodenalis infection in children with persistent diarrhoea

et al. 2019

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Analysis of volatile organic compounds in rats with dopaminergic lesion: Possible application for early detection of Parkinson’s disease

Cited by 18 publications

References 50 publications

A smartphone-based system for detecting hand tremors in unconstrained environments

A smartphone-based system for detecting hand tremors in unconstrained environments

Review on Volatolomic Studies as a Frontier Approach in Animal Research

Identification of volatile biomarkers of Giardia duodenalis infection in children with persistent diarrhoea

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