Analysis of Wild Raspberries (Rubus idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility

Mihailović, Nevena R.; Mihailović, Vladimir; Ćirić, Andrija; Srećković, Nikola; Cvijović, Mirjana R.; Joksović, Ljubinka

doi:10.1007/s11130-019-00756-4

Cited by 28 publications

(17 citation statements)

References 28 publications

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“…Regarding the potassium content, the chico fruit has 517.75 ± 16.78 mg/100 g. Comparing magnesium content with the almonds ( Prunus dulcis ) (270 mg/100 g), which represents a high magnesium content [ 61 ], chico fruit and jiotilla have lower contents in magnesium than almonds. Likewise, comparing with a cactus, Opuntia spp ., it is reported for the pulp fruit content of 76 mg/100 g [ 62 ], the recommended intake per day is around 400–420 mg/per day [ 60 ]. Regarding the potassium content, the chico fruit has 517.75 ± 16.78 mg/100 g, which is a 159 mg/100 g superior to the value presented by the banana ( Musa acuminate ), a fruit with high potassium content, [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

Functional Attributes and Anticancer Potentialities of Chico (Pachycereus Weberi) and Jiotilla (Escontria Chiotilla) Fruits Extract

Sandate-Flores

Romero-Esquivel

Rodríguez‐Rodríguez

et al. 2020

Plants

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Mexico has a great diversity of cacti, however, many of their fruits have not been studied in greater depth. Several bioactive compounds available in cacti juices extract have demonstrated nutraceutical properties. Two cactus species are interesting for their biologically active pigments, which are chico (Pachycereus weberi (J. M. Coult.) Backeb)) and jiotilla (Escontria chiotilla (Weber) Rose)). Hence, the goal of this work was to evaluate the bioactive compounds, i.e., betalains, total phenolic, vitamin C, antioxidant, and mineral content in the extract of the above-mentioned P. weberi and E. chiotilla. Then, clarified extracts were evaluated for their antioxidant activity and cytotoxicity (cancer cell lines) potentialities. Based on the obtained results, Chico fruit extract was found to be a good source of vitamin C (27.19 ± 1.95 mg L-Ascorbic acid/100 g fresh sample). Moreover, chico extract resulted in a high concentration of micronutrients, i.e., potassium (517.75 ± 16.78 mg/100 g) and zinc (2.46 ± 0.65 mg/100 g). On the other hand, Jiotilla has a high content of biologically active pigment, i.e., betaxanthins (4.17 ± 0.35 mg/g dry sample). The antioxidant activities of clarified extracts of chico and jiotilla were 80.01 ± 5.10 and 280.88 ± 7.62 mg/100 g fresh sample (DPPH method), respectively. From the cytotoxicity perspective against cancer cell lines, i.e., CaCo-2, MCF-7, HepG2, and PC-3, the clarified extracts of chico showed cytotoxicity (%cell viability) in CaCo-2 (49.7 ± 0.01%) and MCF-7 (45.56 ± 0.05%). A normal fibroblast cell line (NIH/3T3) was used, as a control, for comparison purposes. While jiotilla extract had cytotoxicity against HepG2 (47.31 ± 0.03%) and PC-3 (53.65 ± 0.04%). These results demonstrated that Chico and jiotilla are excellent resources of biologically active constituents with nutraceuticals potentialities.

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Section: Resultsmentioning

confidence: 99%

Functional Attributes and Anticancer Potentialities of Chico (Pachycereus Weberi) and Jiotilla (Escontria Chiotilla) Fruits Extract

Sandate-Flores

Romero-Esquivel

Rodríguez‐Rodríguez

et al. 2020

Plants

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“…The authors attributed this to the high content of phenolic compounds, similar to that found in WB and CB. In their work, Mihailović et al 93 found an antioxidant capacity of 39.5 μM TE per g for a fresh wild raspberry extract rich in polyphenols, flavonoids and anthocyanins that was subsequently subjected to GID. However, the contribution of these phenolics to AOX was not reported.…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 99%

In vitrogastrointestinal digestion impact on stability, bioaccessibility and antioxidant activity of polyphenols from wild and commercial blackberries (Rubusspp.)

et al. 2021

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“…The absorption and bioavailability of ANTs from raspberries by patients with ileostomy, has been described by González-Barrio et al [43]. After ingestion, the three ANTs found in raspberries (cyanidin-3-glucoside, cyanidin-3-sophoroside, and catechin), along with their metabolites, were not detected in the plasma of healthy or ileostomy volunteers; however, a low level of ANT (<0.1%) absorption in the small intestine was detected in healthy volunteers [85]. The very low absorption of ANTs might be sufficient to facilitate cell signaling, gene regulation, and other biological activities.…”

Section: Anthocyanin Absorption Bioavailability and Metabolismmentioning

confidence: 99%

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

2019

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Anthocyanins (ANTs) are plant pigments that belong to a flavanol class of polyphenols and have diverse pharmacological properties. These compounds are primarily found in fruits and vegetables, with an average daily intake of 180 mgd−1 of these compounds in the developed world. ANTs are potent antioxidants that might regulate the free radical-mediated generation of amyloid peptides (Abeta-amyloids) in the brain, which causes Alzheimer’s disease (AD). This study presents a literature review of ANTs from different berries and their potential therapeutic value, with particular emphasis on neurodegenerative AD, which owing to oxidative stress. This review also highlights reactive oxygen species (ROS) generation through energy metabolism, nitrogen reactive species, the role of transition metals in generating ROS, and the radical-quenching mechanisms of natural antioxidants, including ANTs. The current status of the bioavailability, solubility, and structure activity relationship of ANTs is discussed herein.

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Analysis of Wild Raspberries (Rubus idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility

Cited by 28 publications

References 28 publications

Functional Attributes and Anticancer Potentialities of Chico (Pachycereus Weberi) and Jiotilla (Escontria Chiotilla) Fruits Extract

Functional Attributes and Anticancer Potentialities of Chico (Pachycereus Weberi) and Jiotilla (Escontria Chiotilla) Fruits Extract

In vitrogastrointestinal digestion impact on stability, bioaccessibility and antioxidant activity of polyphenols from wild and commercial blackberries (Rubusspp.)

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

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