Analysis of Y chromosome haplogroups in Japanese population using short amplicons and its application in forensic analysis

Harayama, Yuta; Kamei, Sayako; Sato, Noriko; Hayashi, Tokutaro; Shiozaki, Tetsuya; Ôta, Masao; Asamura, Hideki

doi:10.1016/j.legalmed.2013.10.005

Cited by 2 publications

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“…The haplogroup O1b2a1a1 was the most dominant, and C1a1, C2, D1a2a-M55, D1a2a-12f2b, O1b2, O2a2b1, and O2a1b had frequencies > 5% among the participants. The frequency distributions of the subjects was similar to those of other cohorts (8)(9)(10)(11). The means and standard deviations of birth weight and height for each haplotype are also shown in Table 1.…”

Section: Y Chromosome Haplogroups and Birth Height And Weight In Japa...supporting

confidence: 74%

Y chromosome haplogroups are associated with birth size in Japanese men

Sato

2024

J. Med. Invest.

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The Y chromosome is classified into haplogroups (A-T) based on a combination of several DNA polymorphisms. Japanese men are mainly classified into haplogroups C, D, and O, which have been further subdivided. The distribution of Y-chromosome haplogroups varies by ethnicity. The phylogenetic age, origin, and migration also differ. I hypothesized that Y chromosome haplogroups may be associated with height and/or weight at birth. An association analysis of height and weight at birth with Y chromosome haplogroups was performed in 288 Japanese men. Men belonging to haplogroup O1b2 were significantly associated with short stature at birth (beta = −1.88, standard error (SE) = 0.55, P = 0.00076), and those belonging to D1a2a-12f2b were significantly associated with increased birth weight (beta = 174, SE = 64, P = 0.0069). Y chromosome haplogroups are associated with physical birth characteristics in modern Japanese men.

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Section: Y Chromosome Haplogroups and Birth Height And Weight In Japa...supporting

confidence: 74%

Y chromosome haplogroups are associated with birth size in Japanese men

Sato

2024

J. Med. Invest.

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“…To improve the usefulness of the systems for analyzing degraded DNA samples, we designed primers to render amplicons of 150 bp or shorter. This stems from the fact that past research has already shown that DNA fragmentation is a major obstacle in analyzing degraded DNA samples, and because in STR analysis, we obtained extremely useful results with amplicons 150 bp or smaller . In the assay of the Jomon skeleton, c .260 bp region in the HVS1 failed to be amplified.…”

Section: Resultsmentioning

confidence: 91%

Development of Multiple Assays using 46 SNPs for Comprehensive mtDNA Haplogrouping and Application to Highly Degraded DNA

Nunotani

Sato

Kamei

et al. 2015

Journal of Forensic Sciences

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Six multiplex PCR systems using single-base extension reactions to analyze 46 mitochondrial DNA (mtDNA)-coding region single nucleotide polymorphisms (SNPs) that define 42 haplogroups, that is, 24 major mtDNA haplogroups and 18 subclades, were devised. To improve the usefulness of the established systems for the analysis of degraded DNA samples, novel primers to render amplicons with sizes <150 bp were designed. By applying these systems to 214 Japanese individuals, 24 different haplogroups (power of discrimination = 93.4%) were found. To assess the effectiveness of our systems in grouping degraded DNA, an ancient bone sample of a Jomon skeleton was analyzed and then classified as haplogroup N9b. We conclude that the present systems are powerful screening tools for major haplogroups of mtDNA in addition to the prevalent subhaplogroups in the Japanese population and that these systems are capable of analyzing highly degraded DNA samples in forensic studies.

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Analysis of Y chromosome haplogroups in Japanese population using short amplicons and its application in forensic analysis

Abstract: Analysis of Y chromosome haplogroups in Japanese population using short amplicons and its application in

Cited by 2 publications

References 29 publications

Y chromosome haplogroups are associated with birth size in Japanese men

Y chromosome haplogroups are associated with birth size in Japanese men

Development of Multiple Assays using 46 SNPs for Comprehensive mtDNA Haplogrouping and Application to Highly Degraded DNA

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