Analysis of Y chromosome SNPs in Alagoas, Northeastern Brazil

Azevedo, D.A.; Silva, Luiz Antonio F. da; Gusmão, Leonor; Carvalho, E.F.

doi:10.1016/j.fsigss.2009.08.166

Cited by 11 publications

(12 citation statements)

References 5 publications

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“…1Pontes et al , 2007;2Melo et al , 2011;3Palha et al , 2010;4current study;5Azevedo et al , 2009;6Grattapaglia et al , 2005;7Góis et al , 2007;8Palha et al , 2007;9Schwengber et al , 2009.…”

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Haplotype diversity of 17 Y-str loci in an admixed population from the Brazilian Amazon

Francez

Ramos²,

Palha

et al. 2011

Genet. Mol. Biol.

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The allelic and haplotype frequencies of 17 Y-STR loci most commonly used in forensic testing were estimated in a sample of 138 unrelated healthy males from Macapá, in the northern Amazon region of Brazil. The average gene diversity was 0.6554 ± 0.3315. 134 haplotypes of the 17 loci were observed, 130 of them unique and four present in two individuals each. The haplotype diversity index was 0.9996 + 0.0009, with the most frequent haplogroups being R1b (52.2%), E1b1b (11.6%), J2 (10.1%) and Q (7.2%). Most haplogroups of this population belonged to European male lineages (89.2%), followed by Amerindian (7.2%) and African (3.6%) lineages.

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Section: Tableunclassified

Haplotype diversity of 17 Y-str loci in an admixed population from the Brazilian Amazon

Francez

Ramos²,

Palha

et al. 2011

Genet. Mol. Biol.

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“…We have demonstrated heterogenous frequencies of mitochondrial Amerindian and African lineages in the Brazilian Northeast, which brought a new perspective to the understanding of the maternal ancestral contributions to this region (13). An insight into the paternal lineages of this same population is important to determine whether male contributions were also distinct from earlier reports and to what extent the numerous historical immigrations influenced the genetic architecture of this region (7,9).…”

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confidence: 76%

“…Uniparental markers are useful for disentangling the complex processes that shaped the current population (6). Indeed, previous data from maternal and paternal lineages (using both slow and fast evolving markers) has shown a strong male biased colonization of the Brazilian territory, with the majority of mitochondrial DNA (mtDNA) haplogroups being of Native American and African origin, while Y-chromosome lineages are overwhelmingly dominated by European haplogroups (7)(8)(9)(10)(11)(12)(13)(14). We have demonstrated heterogenous frequencies of mitochondrial Amerindian and African lineages in the Brazilian Northeast, which brought a new perspective to the understanding of the maternal ancestral contributions to this region (13).…”

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confidence: 99%

New insights on intercontinental origins of paternal lineages in Northeast Brazil

et al. 2020

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Background: The current Brazilian population is the product of centuries of admixture between intercontinental founding groups. Although previous results have revealed a heterogeneous distribution of mitochondrial lineages in the Northeast region, the most targeted by foreign settlers during the sixteenth century, little is known about the paternal ancestry of this particular population. Considering historical records have documented a series of territorial invasions in the Northeast by various European populations, we aimed to characterize the male lineages found in Brazilian individuals in order to discover to what extent these migrations have influenced the present-day gene pool. Our approach consisted of employing four hierarchical multiplex assays for the investigation of 45 unique event polymorphisms in the non-recombining portion of the Y-chromosome of 280 unrelated men from several Northeast Brazilian states. Results: Primary multiplex results allowed the identification of six major haplogroups, four of which were screened for downstream SNPs and enabled the observation of 19 additional lineages. Results reveal a majority of Western European haplogroups, among which R1b-S116* was the most common (63.9%), corroborating historical records of colonizations by Iberian populations. Nonetheless, F ST genetic distances show similarities between Northeast Brazil and several other European populations, indicating multiple origins of settlers. Regarding Native American ancestry, our findings confirm a strong sexual bias against such haplogroups, which represented only 2.5% of individuals, highly contrasting previous results for maternal lineages. Furthermore, we document the presence of several Middle Eastern and African haplogroups, supporting a complex historical formation of this population and highlighting its uniqueness among other Brazilian regions. Conclusions: We performed a comprehensive analysis of the major Y-chromosome lineages that form the most dynamic migratory region from the Brazilian colonial period. This evidence suggests that the ongoing entry of European, Middle Eastern, and African males in the Brazilian Northeast, since at least 500 years, was significantly responsible for the present-day genetic architecture of this population.

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“…A população brasileira descende principalmente de ameríndios, africanos e europeus, porém o casamento entre estes indivíduos de origens étnicas diferentes deu origem a uma grande variação genética [53][54][55], tornando a população do Brasil altamente heterogênea. Com relação ao uso de DNA para determinação de características fenotípicas na população brasileira, os estudos ainda são muito iniciais.…”

Section: Perspectivasunclassified

“…Com relação ao uso de DNA para determinação de características fenotípicas na população brasileira, os estudos ainda são muito iniciais. Grupos de diferentes regiões do país tem buscado relacionar SNPs previamente descritos e associados com a pigmentação do cabelo, pele e olhos na população brasileira e, embora alguns desses marcadores tenham se mostrado tão eficiente aqui como em outros lugares, outros já não possuem alto poder preditivo em uma população tão miscigenada [55,56]. Assim, ainda há muito o que pesquisar e investir para podermos utilizar testes preditivos de fenótipo.…”

Section: Perspectivasunclassified

Fenotipagem forense pelo DNA através de SNPs

Virmond¹,

Robert²,

Brito³

et al. 2016

Rev. Bras. Crimin.

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A fenotipagem forense pelo DNA se apresenta como uma abordagem promissora para suprir lacunas na busca de pessoas desconhecidas, em investigaÃ§Ãµes criminais, e na identificaÃ§Ã£o de vÃtimas de catÃ¡strofes e de pessoas desaparecidas. Essa metodologia permite a previsÃ£o individual de caracterÃsticas externamente visÃveis (CEVs) a partir de anÃ¡lises com SNPs informativos de fenÃ³tipos. Entre esses SNPs, os mais bem descritos sÃ£o aqueles relacionados com as caracterÃsticas de pigmentaÃ§Ã£o, como cor dos olhos, pele e cabelo. Estudos vÃªm demonstrando o elevado poder de prediÃ§Ã£o dessas CEVs, apresentando resultados satisfatÃ³rios na prediÃ§Ã£o da cor de Ãris castanha e azul e cabelo ruivo, enquanto para as demais ainda sÃ£o necessÃ¡rias mais pesquisas para predizer com precisÃ£o esses fenÃ³tipos. Embora seja muito promissora, a aplicaÃ§Ã£o prÃ¡tica da fenotipagem forense pelo DNA levanta diversas questÃµes de ordem Ã©tica e legal. No Brasil, avanÃ§os ainda precisam acontecer, uma vez que a populaÃ§Ã£o brasileira Ã© heterogÃªnea e grande parte dos marcadores descritos Ã© relacionada Ã s populaÃ§Ãµes europeias. Neste sentido, o Brasil jÃ¡ conta com a Rede Integrada de Bancos de Perfis GenÃ©ticos (RIBPG), a qual visa compartilhar e comparar os perfis genÃ©ticos entre os bancos do paÃs. Em um futuro prÃ³ximo essa metodologia estarÃ¡ apta a integrar Ã s rotinas forenses, com grande aplicabilidade e confiabilidade.

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Analysis of Y chromosome SNPs in Alagoas, Northeastern Brazil

Cited by 11 publications

References 5 publications

Haplotype diversity of 17 Y-str loci in an admixed population from the Brazilian Amazon

Haplotype diversity of 17 Y-str loci in an admixed population from the Brazilian Amazon

New insights on intercontinental origins of paternal lineages in Northeast Brazil

Fenotipagem forense pelo DNA através de SNPs

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