Analysis of young ischemic stroke patients in northeast China

Ge, Jiaojiao; Xing, Yingqi; Chen, Hong-Xiu; Wang, Li Juan; Cui, Li

doi:10.21037/atm.2019.12.72

Cited by 14 publications

(5 citation statements)

References 44 publications

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“…Therefore, some researchers have suggested local body fat distribution index (such as WC) was more strongly associated with CVD outcomes than BMI, 26 because an increase in BMI resulted from an increase in subcutaneous or visceral adipose tissue (or both). [25][26][27][28] Although many studies suggested WC, which can reflect body fat distribution and upper body obesity, as a better indicator of cardiometabolic risk than BMI, this study did not find a significant association of WC with premature ASCVD. Since the distribution and composition of visceral adiposity at different ages may present different levels of ASCVD risk, our findings suggest for the younger population, BMI may be a better predictor of premature ASCVD than WC.…”

Section: Table 1 (Continued)contrasting

confidence: 83%

Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China: A Longitudinal Analysis of the China Health and Nutrition Survey Cohort

Ding,

Zhou,

Han

et al. 2024

Asia Pac J Public Health

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The burden of premature atherosclerotic cardiovascular disease (ASCVD) has increased rapidly in China. Using the China Health and Nutrition Survey (CHNS) data, we assessed the risk factors of premature ASCVD (age of diagnosis: <55 years for men and <65 years for women). Propensity score matching was used to reduce selection bias. Multivariable Cox proportional-hazards analyses indicated that factors associated with increased risk of premature ASCVD included hypertension (adjusted hazard ratio [HRadj.] = 1.68, 95% confidence interval [CI] = [1.14, 2.48]), obesity (HRadj. = 1.64, 95% CI = [1.03, 2.61]), and high carbohydrate intake (HRadj. = 1.46, 95% CI = [1.03, 2.08]). Conversely, participants with medical insurance (HRadj. = 0.42, 95% CI = [0.28, 0.61]), high urbanization index (HRadj. = 0.53, 95% CI = [0.33, 0.85]), and high household income (HRadj. = 0.48, 95% CI = [0.33, 0.71]) had lower risk of premature ASCVD. When comparing premature vs non-premature ASCVD participants, those who were obese (HRadj. = 2.08, 95% CI = [1.14, 3.80]) or living in more urbanized areas had higher hazards of early onset (HRadj. = 2.29, 95% CI = [1.33, 3.94]).

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Section: Table 1 (Continued)contrasting

confidence: 83%

Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China: A Longitudinal Analysis of the China Health and Nutrition Survey Cohort

Ding,

Zhou,

Han

et al. 2024

Asia Pac J Public Health

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“…In addition, it should be noted that this was a young patient. A study on ischemic stroke in young adults found that up to 55.3% patients had Dyslipidemia [ 7 ]. The rationale for using aggressive lipid-lowering therapy in young patients with intracranial stenosis lies in the fact that they have a shorter course of arteriosclerosis, which is the underlying cause of stenosis.…”

Section: Discussionmentioning

confidence: 99%

Case report: Intensive statin and PCSK-9 inhibitor combo reduces plaque volume and stenosis in ischemic stroke patient

Zeng

Shi²,

Fan

et al. 2023

Heliyon

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“…Large artery atherosclerosis (LAA) accounts for about 25% of acute ischemic stroke (AIS). This type of stroke is apt to progress and reoccur, with result of higher disability and higher mortality (Ge et al., 2020 ; Ois et al., 2013 ). Early reperfusion therapy such as intravenous thrombolysis and endovascular treatment is the most effective method, but only a few patients can receive these treatments due to time window and technical limitations (Wardlaw et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Safety and preliminary efficacy of argatroban plus dual antiplatelet therapy for acute mild to moderate ischemic stroke with large artery atherosclerosis

Hou

Cui

et al. 2022

Brain and Behavior

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Objective Previous studies suggest the benefit of dual antiplatelet therapy (DAPT) for acute ischemic stroke with large artery atherosclerosis (LAA) etiology, but there is no study about the effect of DAPT plus anticoagulant in this population. Methods A prospective single arm trial was performed to determine the effect of DAPT combined with argatroban on acute mild to moderate ischemic stroke patients with LAA, which was compared with historical populations. The main outcome was the proportion of early neurological deterioration (END). The secondary outcomes included scores of 0 to 1 and 0 to 2 on the modified Rankin Scale (mRS) at 90 days, and changes in National Institutes of Health Stroke Scale (NIHSS) from baseline to day 7 after admission. The safety outcomes included intracranial hemorrhage at 7 days, organ hemorrhage, and all‐cause mortality at 90 days. Results A total of 120 patients with argatroban plus DAPT were prospectively enrolled and 529 patients with only DAPT were retrospectively collected. There was no significant difference in baseline characteristics between groups. Compared with control group, combined treatment group had lower proportion of END (4.2% vs. 10.0%, adjusted p = .046), more reduction in NIHSS score from the baseline to day 7 after admission (1.06 ± 2.03 vs. 0.39 ± 1.97, adjusted p = .003), and higher proportion of mRS (0–2) at 90 days (87.5% vs. 79.2%, adjusted p = .048). No intracranial hemorrhage was found between groups. Conclusions This is the first report that short‐term argatroban combined with DAPT seems to be safe and may effectively prevent END and improve neurological prognosis for acute mild to moderate ischemic stroke patients with LAA; however, interpretation of the conclusion required caution due to nonrandomized controlled trial with medium sample size.

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Analysis of young ischemic stroke patients in northeast China

Cited by 14 publications

References 44 publications

Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China: A Longitudinal Analysis of the China Health and Nutrition Survey Cohort

Risk Factors of Premature Atherosclerotic Cardiovascular Disease in China: A Longitudinal Analysis of the China Health and Nutrition Survey Cohort

Case report: Intensive statin and PCSK-9 inhibitor combo reduces plaque volume and stenosis in ischemic stroke patient

Safety and preliminary efficacy of argatroban plus dual antiplatelet therapy for acute mild to moderate ischemic stroke with large artery atherosclerosis

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