The combination support structure of pile-anchor and frame-anchor is widely used in multi-level slope engineering, but the relevant theoretical research lags behind engineering practice. To make up for this deficiency, this paper takes the multi-level slope under combined support of pile-anchor and frame-anchor as the research object, conducts a model test using the geotechnical centrifuge, analyzes the most relevant structural force and slope deformation in engineering, and provides some reinforcement suggestions. The test results show that the combination support structure of pile-anchor and frame-anchor has a good reinforcement effect on multi-level soil slopes, but the deformation range of the slope is greatly affected by the anchoring structure and the anchor rods located within the deformation zone. The structural force condition is significantly different from traditional structures that place the anchor rod anchoring section in a stable soil layer. According to the structural force characteristics, it is recommended that the support design fully consider the positional relationship between the anchor rods and the sliding surface. The design of the frame-anchor support section should strictly control the anchoring depth, so that the potential sliding surface of the slope can be moved backward, thereby increasing the difficulty of sliding. The design of pile-anchor support should ensure that the anchor rods have sufficient length to provide greater anchoring force, thereby improving the bearing capacity of the pile. These research results can enrich and improve the support design theory of multi-level soil slopes, providing guidance for engineering practice.