Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery

Culver, Heidi R.; Clegg, John R.; Peppas, Nicholas A.

doi:10.1021/acs.accounts.8b00411

Cited by 52 publications

(60 citation statements)

References 30 publications

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“…In recent years, AuNPs have gained significant interest due to their unique conductive [34], optical [35][36][37], and magnetic properties [38,39]. These characteristics have been shown to be particularly advantageous for the development of biosensors [40], and drug delivery systems [41], as well as various tissue engineering applications [42]. Apart from their ease of synthesis, their high stability [40] and biocompatibility [36][37][38], the ability to fine tune the properties of AuNPs by varying their size and shape make them attractive candidates for the synthesis of ECHs.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

“…Moreover, ECHs respond to applied electrical fields either by swelling, shrinking, bending, or other structural changes due to minor differences in the electric potential across the hydrogel [200]. Previous studies demonstrated that HA-, alginate-, and chitosan-based hydrogels possess intrinsic electroactive properties due to the presence of acidic or basic ionic groups throughout their polymer networks [41]. However, their low electrical responsiveness and poor mechanical performance limit their application for implantable smart systems for long-term drug delivery [12].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

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Rational design of microfabricated electroconductive hydrogels for biomedical applications

Walker

Portillo-Lara

Mogadam

et al. 2019

Progress in Polymer Science

167

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Electroconductive hydrogels (ECHs) are highly hydrated three-dimensional (3D) networks generated through the incorporation of conductive polymers, nanoparticles, and other conductive materials into polymeric hydrogels. ECHs combine several advantageous properties of inherently conductive materials with the highly tunable physical and biochemical properties of hydrogels. Recently, the development of biocompatible ECHs has been investigated for various biomedical applications, such as tissue engineering, drug delivery, biosensors, flexible electronics, and other implantable medical devices. Several methods for the synthesis of ECHs have been reported, which include the incorporation of electrically conductive materials such as gold and silver nanoparticles, graphene, and carbon nanotubes, as well as various conductive polymers (CPs), such as polyaniline, polypyrrole, and poly(3,4-ethylenedioxyythiophene) into hydrogel networks. These electroconductive composite hydrogels can be used as scaffolds with high swellability, tunable mechanical properties, and the capability to support cell growth both in vitro and in vivo. Furthermore, recent advancements in microfabrication techniques such as 3D bioprinting, micropatterning, and electrospinning have led to the development of ECHs with biomimetic microarchitectures that reproduce the characteristics of the native extracellular matrix (ECM). The combination of sophisticated synthesis chemistries and modern microfabrication techniques have led to engineer smart ECHs with advanced architectures, geometries, and functionalities that are being increasingly used in drug delivery systems, biosensors, tissue engineering, and soft electronics. In this review, we will summarize different strategies to synthesize conductive biomaterials. We will also discuss the advanced microfabrication techniques used to fabricate ECHs with complex 3D architectures, as well as various biomedical applications of microfabricated ECHs.

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Section: Gold Nanoparticlesmentioning

confidence: 99%

Section: Drug Delivery Systemsmentioning

confidence: 99%

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Walker

Portillo-Lara

Mogadam

et al. 2019

Progress in Polymer Science

167

View full text Add to dashboard Cite

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“…[10][11][12][13][14][15] The latter application involves the use of hydrogels to deliver pharmaceuticals into the body, where they can be subsequently released in a controlled way. Hydrogels are extremely versatile, [16][17][18] and their porous structure can be easily modified, for example by changing the cross-linking density, to load and transport pharmaceuticals to specific target tissues. [19] Hydrogel-based products can be prepared in a variety of different formulations, spanning a wide range of drug administration routes.…”

Section: Introductionmentioning

confidence: 99%

Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties

Castiglione

Casalegno

Ferro

et al. 2019

Journal of Controlled Release

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Polymeric hydrogels are promising candidates for drug delivery applications, thanks to their ability to encapsulate, transport and release a wide range of chemicals. The successful application of these materials requires a deep understanding of the mechanisms governing solute transport at the nanoscale and its impact on release kinetics. In this work, we investigate the translational diffusion of ibuprofen loaded in anionic agarose-carbomer (AC) hydrogels by 1 H high resolution magic angle spinning (HR-MAS) NMR spectroscopy, and compare it to its macroscopic release kinetics. The analysis of the experimental NMR data provides the first evidence of superdiffusion for ibuprofen in AC hydrogels. Superdiffusive transport is observed in the majority of our samples, especially those with the smallest mesh size (7 nm) and highest ibuprofen concentrations (90-120 mg/mL). This outcome is rationalized in terms of heavy-tailed distributions of spatial displacements (Lèvy flights) and of waiting times, which depend on the nanoscopic structural heterogeneity of the gels and the strong but reversible association between ibuprofen and the agarose matrix.

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“…With stimuli-responsive materials (11)(12)(13), more possibilities will open not only for drug delivery but also for advanced regenerative medicine and for 4D constructs in which form can change after implantation in response to internal or external stimuli.…”

Section: Other Toolsmentioning

confidence: 99%

Pulling and Pushing Stem Cells to Control Their Differentiation

Ashammakhi

Kaarela

Ferretti

2018

Journal of Craniofacial Surgery

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Much has already been done to achieve precisely controlled and customised regenerative therapies. Thanks to recent advances made in several areas relevant to regenerative medicine including the use of stimuli-responsive materials, 4-dimensional biofabrication, inducible pluripotent stem cells, control of stem cell fate using chemical and physical factors, minimal access delivery, and information-communication technology. In this short perspective, recent advances are discussed with a focus on a recent report on the use of mechanical stretching of nanoparticle-laden stem cells by using external magnetic field to induce defined cardiac line differentiation. Although more and more tools are becoming available for engineering tissue models tissues and the range of potential applications is expanding, there is still much work to be done before it is proved to work with human cells, form tissues and ultimately achieve application in the clinic.

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Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery

Cited by 52 publications

References 30 publications

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties

Pulling and Pushing Stem Cells to Control Their Differentiation

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