Analytical and bioanalytical approaches to unravel the selenium–mercury antagonism: A review

Luque-García, José L.; Cabezas-Sánchez, Pablo; Anunciação, Daniela Santos; Cámara, Carmen

doi:10.1016/j.aca.2013.08.043

Cited by 35 publications

(14 citation statements)

References 55 publications

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“…A possible role for fish consumption could be discussed since it is also an important source of selenium, iodine and other elements which could reduce thyroid cancer risk (Köhrle et al, 1999;Cléro et al, 2012;Luque-Garcia et al, 2013).…”

Section: Study Limitationsmentioning

confidence: 99%

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

Zidane¹,

Ren²,

Xhaard³

et al. 2019

Asian Pac J Cancer Prev

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Background:In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer.Objective:The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods:The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association between thyroid cancer risk and daily intake levels of nETE and with fingernail nETE levels.Results:Hg contamination was mainly present in sea products, Pb contamination was present in almost all samples, Cd was detectable in starchy food and As was detectable in all sea products. No patient exceeded dietary contamination WHO limits for Pb, 2 participants exceeded it for Hg and 3 individuals (0.5%) for cadmium. In fingernail clippings, the most detectable pollutant was Pb (553 participants), then Hg (543 participants) then Cd (only in 130 participants). Thyroid cancer risk was increased more than 4 times by Pb daily intake in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.01), and 2 times more in women with more than 3 pregnancies than in those with none or less (p for interaction =0.005); it was also increased following As intake by more than 30% in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.05). Conclusion:Locally produced foods are not a source of nETE exposure in French Polynesia. Dieatry nETE exposure and fingernail nETE concentration are not associated to differentiated thyroid cancer risk. No correlation found between nETE dietary exposure and fingernail nETE concentration.

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Section: Study Limitationsmentioning

confidence: 99%

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

Zidane¹,

Ren²,

Xhaard³

et al. 2019

Asian Pac J Cancer Prev

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“…Assays for cellular metabolic activity, oxidative stress evaluation, apoptosis detection, and cell membrane integrity49, 50, 51, 52, 53, 54, 55 have been developed for analyzing cytotoxicity of chemicals and these are widely used also in NM‐induced cytotoxicity screening. The methods are time‐consuming, labor‐intensive, complex, and in some instances unreliable owing to NM interferences 53, 56, 57.…”

Section: High‐throughput Screening For Nm‐induced Cytotoxicitymentioning

confidence: 99%

“…The methods are time‐consuming, labor‐intensive, complex, and in some instances unreliable owing to NM interferences 53, 56, 57. The reagents employed in such methods may interact with some of the tested NMs or may interfere with spectrophotometric readings, leading to unreliable results 49, 50, 55. Conventional assays focus on specific endpoints, without providing information about the dynamic biological processes leading to those endpoints, or the specific time points and concentrations at which different toxic effects are induced by NMs 54, 58.…”

Section: High‐throughput Screening For Nm‐induced Cytotoxicitymentioning

confidence: 99%

High throughput toxicity screening and intracellular detection of nanomaterials

Collins

Annangi

Rubio

et al. 2016

WIREs Nanomed Nanobiotechnol

116

106

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With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical dilemmas associated with animal research. Data are needed for developing intelligent testing strategies for risk assessment of NMs, based on grouping and read‐across approaches. The adoption of high throughput screening (HTS) and high content analysis (HCA) for NM toxicity testing allows the testing of numerous materials at different concentrations and on different types of cells, reduces the effect of inter‐experimental variation, and makes substantial savings in time and cost. HTS/HCA approaches facilitate the classification of key biological indicators of NM‐cell interactions. Validation of in vitro HTS tests is required, taking account of relevance to in vivo results. HTS/HCA approaches are needed to assess dose‐ and time‐dependent toxicity, allowing prediction of in vivo adverse effects. Several HTS/HCA methods are being validated and applied for NM testing in the FP7 project NANoREG, including Label‐free cellular screening of NM uptake, HCA, High throughput flow cytometry, Impedance‐based monitoring, Multiplex analysis of secreted products, and genotoxicity methods—namely High throughput comet assay, High throughput in vitro micronucleus assay, and γH2AX assay. There are several technical challenges with HTS/HCA for NM testing, as toxicity screening needs to be coupled with characterization of NMs in exposure medium prior to the test; possible interference of NMs with HTS/HCA techniques is another concern. Advantages and challenges of HTS/HCA approaches in NM safety are discussed. WIREs Nanomed Nanobiotechnol 2017, 9:e1413. doi: 10.1002/wnan.1413For further resources related to this article, please visit the WIREs website.

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“…glutathione peroxidase, GPX; thioredoxin reductase, TrxR), and supplemental Se could reduce the Hg-induced depletion of selenoenzymes. 12, 13 Related to the first two hypotheses, it has been specifically postulated that the protective effects of Se occur when the molar Se/Hg molar ratio is ≥1 because Se may reduce the biological availability of Hg through physical sequestration due to the high affinity between Hg and Se. 14–17 Potential mechanisms for synergism are less clear, but may include altering antioxidant capabilities, thereby promoting a prooxidative environment.…”

Section: Introductionmentioning

confidence: 99%

Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios

Wyatt

Diringer

Rogers

et al. 2016

Environ. Sci. Technol.

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The relationship between mercury (Hg) and selenium (Se) toxicity is complex, with coexposure reported to reduce, increase, and have no effect on toxicity. Different interactions may be related to chemical compound, but this has not been systematically examined. Our goal was to assess the interactive effects between the two elements on growth in the nematode Caenorhabditis elegans, focusing on inorganic and organic Hg (HgCl2 and MeHgCl) and Se (selenomethionine, sodium selenite, and sodium selenate) compounds. We utilized aqueous Hg/Se dosing molar ratios that were either above, below, or equal to 1 and measured the internal nematode total Hg and Se concentrations for the highest concentrations of each Se compound. Observed interactions were complicated, differed between Se and Hg compounds, and included greater-than-additive, additive, and less-than-additive growth impacts. Biologically significant interactions were only observed when the dosing Se solution concentration was 100–25 000 times greater than the dosing Hg concentration. Mitigation of growth impacts was not predictable on the basis of internal Hg/Se molar ratio; improved growth was observed at some internal Hg/Se molar ratios both above and below 1. These findings suggest that future assessments of the Hg and Se relationship should incorporate chemical compound into the evaluation.

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Analytical and bioanalytical approaches to unravel the selenium–mercury antagonism: A review

Cited by 35 publications

References 55 publications

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

High throughput toxicity screening and intracellular detection of nanomaterials

Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios

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