Analytical and biological variability of serum creatinine and creatinine clearance: implications for clinical interpretation.

Rosano, Thomas G.; Brown, H

doi:10.1093/clinchem/28.11.2330

Cited by 24 publications

(4 citation statements)

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“…The renal function was evaluated with the serum level of creatinine ( μ mol/l), according to the biochemical reaction of Jaffe (2). cGFR was estimated with the Schwartz formula [(3): K × T (cm)/creatinine (mg/dL) ( K = 0.45 < 18 months of age, K = 0.55 between 18 months and the beginning of the puberty for the boys and 16 yr for the girls, K = 0.7 for the boys after 13 yr].…”

Section: Methodsmentioning

confidence: 99%

Renal function outcome in pediatric liver transplant recipients

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Lahoche-Manucci

Bonnevalle

et al. 2005

Pediatric Transplantation

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The orthotopic liver transplantation (OLT) allows survival of children followed for severe hepatic injury, provided that the immunosuppressive treatment is prolonged. The nephrotoxicity of cyclosporine predicts the long-term outcome of the adult patients receiving a liver transplant. The aim of this study was to determine the long-term outcome of renal function in children receiving OLT. This study included 12 children, with a median for age of 7.1 yr (2-15 yr) at the time of OLT. The duration of follow-up was at least 4 yr, being 7 yr in 10 patients and more than 10 yr in seven. Renal function was evaluated with the serum level of creatinine, calculated glomerular filtration rate (cGFR), and measurement of glomerular filtration rate using chrome 51 ethylenediaminetetraacetate ((51)Cr EDTA) clearance performed at least once during follow-up. The doses and the serum concentrations (C(0)) of cyclosporine were reported at each study time. The cGFR decreased significantly 2 yr after the OLT [median (range): 106 mL/min/1.73 m(2) (71-150) at the time of OLT vs. 85 mL/min/1.73 m(2) (57-128) 2 yr after the OLT, p = 0.03], and decreased again between 7 and 10 yr after OLT [median (range): 99 mL/min/1.73 m(2) (76-125) 7 yr after OLT vs. 81 mL/min/1.73 m(2) (66-140) 10 yr after OLT, p = 0.04]. Six patients developed chronic renal failure (cGFR from 57 to 80 mL/min/1.73 m(2)) 2 yr after OLT associated with high doses of cyclosporine [median (range): 8.8 mg/kg/day (3.5-13)]. The cGFR overestimated renal function by 16% compared with the isotopic measurement of GFR (p = 0.03). Using the (51)Cr EDTA measurement, six of seven patients followed up more than 10 yr after OLT presented mild (n = 3) or moderate (n = 3) chronic renal failure. In our study, the majority of OLT recipients developed a chronic renal failure 10 yr after transplantation. Cyclosporine seems to be the most important factor responsible for the impairment of renal function. The use of the mycophenolate mofetil, a new immunosuppressive agent, allowing a reduction in the dose of cyclosporine, could minimize renal dysfunction. While awaiting the results of a prospective long-term study, close drug monitoring is advised.

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Section: Methodsmentioning

confidence: 99%

Renal function outcome in pediatric liver transplant recipients

Mention

Lahoche-Manucci

Bonnevalle

et al. 2005

Pediatric Transplantation

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“…Our results for creatinine in urine showed a peak at 36–48 h, which could be due to passive reabsorption across immature renal tubules that occurs in the first days of life [ 33 , 34 ]. In addition, in those first days, there are more intense changes, both in the hemodynamic and intravascular space, as well as elevation of bilirubin, which would produce greater variability in creatinine levels [ 35 ]. Further research is necessary to improve our understanding of the kinetics of renal function and biomarkers of OS in the evolution of neonates.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birth

Cavia-Saiz,

Arnaez,

Cilla

et al. 2023

Antioxidants

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The clinical relevance of stress biomarkers in newborns is well established. Currently, oxidative stress (OS) parameters are seen to play an important role in neonatal resuscitation guidelines, and a link has been observed between the amount of oxygen delivered and the level of OS and the development of various pathologies. The aim of the current study was to investigate changes in neonatal plasma and urine OS status during the first hours after birth. A lower antioxidant capacity (TAC) and higher levels of malondialdehyde in blood were observed in newborns at the time of birth compared with results 48 h postnatally. The urine revealed a significant and progressive increase in TAC and creatinine during the first 36 h of life, with a progressive decline thereafter. Meanwhile, malondialdehyde in urine samples showed no significant differences over time. Overall, the correlation between blood and urine parameters was poor, except for the relationship between umbilical vein glutathione reduced/oxidized ratio and urine malondialdehyde (r = 0.7; p = 0.004) and between TAC in the umbilical artery and urine (r = −0.547; p = 0.013). The biomarkers evaluated in this study could be established as reference values for neonatal OS.

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“…The determination of liver and kidney function parameters such as AST [11], ALT [12], AP [13], Creatinine [14], total proteins [15], triglycerides [16], albumin [17], HDL-cholesterol [18], urea [19] were carried out using a commercial assay kit (Chronolab SYS S.L. Avenida diagonal 609, planta 10, DRU28 Barcelona.…”

Section: Dosage Of Alt Ast Ap Creatinine Total Proteins Hdl-cholester...mentioning

confidence: 99%

Evaluation of Hepatoprotective Activity and Acute Toxicity of Guiera Senegalensis Leaf Extract on Wistar Rats

Hayatou,

Tembe,

Herve

et al. 2024

JAMPS

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A liver is an essential organ that performs several metabolic activities in body. Various chemicals as well as pathologies which affecting it result in harmful consequences. Management of liver pathologies involves expensive and even toxic therapeutic strategies. 80 % by populations in developing countries used medicinal plants which constituted a significant reservoir of molecules with diverse and various properties including hepatoprotective properties. To rectify these problems, Guiera senegalensis has been in existence that subjected to few studies and highlighted hepatoprotective properties, hence the interest of this study. Three extraction methods were carried out, infusion, decoction, maceration (aqueous, ethanolic). The hepatoprotective activity of the extracts was explored on 42 Wistar rats divided into 7 groups of 6 rats each. The groups including 4 test groups, were treated with the extract at 500 mg/kg of each extract. A healthy group that received distilled water (positive control group) were treated with paracetamol at 640mg/Kg. A reference group received a drug (Silymarin) The rats were treated for 14 days. The rats were then sacrificed, blood sample were collected for biochemical analyses. Some organs were removed for histological analysis as well. The acute toxicity of the extract obtained by hydro-ethanolic maceration at a dose of 2000 mg/kg was conducted in accordance with OECD guideline 420. The study of the hepatoprotective activity of plant extracts showed a significant decrease in transaminase activities in the rats treated with the extract obtained by aqueous maceration, AP, a significant decrease in total proteins in the extract obtained by hydro-ethanolic maceration. It was revealed that, the increase in in-vivo antioxidants found to be high in those treated with the hydro-ethanolic extract. The hydro-ethanolic extract did not show any significant toxicity.

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Analytical and biological variability of serum creatinine and creatinine clearance: implications for clinical interpretation.

Cited by 24 publications

References 0 publications

Renal function outcome in pediatric liver transplant recipients

Renal function outcome in pediatric liver transplant recipients

Biomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birth

Evaluation of Hepatoprotective Activity and Acute Toxicity of Guiera Senegalensis Leaf Extract on Wistar Rats

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