Analytical and diagnostic aspects of carbohydrate deficient transferrin (CDT): A critical review over years 2007–2017

Bortolotti, Federica; Sorio, Daniela; Bertaso, Anna; Tagliaro, Franco

doi:10.1016/j.jpba.2017.09.006

Cited by 50 publications

(41 citation statements)

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“…For example, the biomarkers measuring liver enzymes provide information only about the functionality of the liver but not the cause of damage. Another biomarker, the percentage of carbohydrate deficient transferrin (%CDT), can be elevated due to severe liver disease or due to pregnancy (Bortolotti et al, 2018;Gough et al, 2015). Recently, phosphatidylethanols have been introduced as selective biomarkers for alcohol use, but they need to be measured from samples not collected routinely (whole blood or tissues) because phosphatidylethanols are an integral part of cell membranes (Zheng, Beck, & Helander, 2011).…”

Section: Introductionmentioning

confidence: 99%

Changes in the Human Metabolome Associated With Alcohol Use: A Review

Voutilainen

Kärkkäinen

2019

Alcohol and Alcoholism

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Aims: The metabolome refers to the functional status of the cell, organ, or the whole body. Metabolomic methods measure the metabolome (metabolite profile) which can be used to examine disease progression and treatment responses. Here, our aim was to review metabolomics studies examining effects of alcohol use in humans. Methods: We performed a literature search using PubMed and Web of Science for reports on changes in the human metabolite profile associated with alcohol use; we found a total of 23 articles published before end of 2018. Results: Most studies had investigated plasma, serum or urine samples; only four studies had examined other sample types (liver, faeces, and broncho-alveolar lavage fluid). Levels of 51 metabolites were altered in two or more of the reviewed studies. Alcohol use was associated with changes in the levels of lipids and amino acids. In general, levels of fatty acids, phosphatidylcholine diacyls and steroid metabolites tended to increase, whereas those of phosphatidylcholine acyl-alkyls and hydroxysphingomyelins declined. Common alterations in circulatory levels of amino acids included decreased levels of glutamine, and increased levels of tyrosine and alanine. Conclusions: More studies, especially with a longitudinal study design, or using more varied sample materials (e.g. organs or saliva), are needed to clarify alcohol-induced diseases and alterations at a target organ level. Hopefully, this will lead to the discovery of new treatments, improved recognition of individuals at high risk and the identification of those subjects who would benefit most from certain treatments.

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Section: Introductionmentioning

confidence: 99%

Changes in the Human Metabolome Associated With Alcohol Use: A Review

Voutilainen

Kärkkäinen

2019

Alcohol and Alcoholism

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“…However, CDT and GGT may be influenced by other factors besides alcohol intake, including smoking, gender, age, and various diseases (Andresen‐Streichert et al, 2018; Conigrave et al, 2003; Neumann et al, 2020). The sensitivity of CDT for detecting recent alcohol use may be as low as 50 to 70%, and false positives for CDT, though rare, can be caused by genetic variants of transferrin, severe liver disease, and pregnancy (Bortolotti, Sorio et al, 2018).…”

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confidence: 99%

Relationship of Phosphatidylethanol Biomarker to Self‐Reported Alcohol Drinking Patterns in Older and Middle‐Age Adults

Cherrier

Shireman

Wicklander

et al. 2020

Alcoholism Clin & Exp Res

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Background: Risky alcohol consumption is on the rise among older adults. Biomarkers such as phosphatidylethanol (PEth) have been used to evaluate the correspondence between an objective, laboratory-based biomarker and self-report of alcohol consumption. This study examined the relationship between PEth, self-report of alcohol consumption, and health indices in a sample of community-dwelling older to middle-age adults (aged 35 to 89) with healthy and risky levels of alcohol consumption. Methods: Self-reports of alcohol consumption were collected using the Alcohol Use Disorders Identification Test (AUDIT) and Form 30. In addition, indices of health along with a blood sample to determine PEth values were collected (N = 183). Results: PEth was correlated with age, AUDIT-C, AUDIT total, alcohol consumption, mood, and liver function measures but not with medical comorbidity or body mass index (J Gerontol B Psychol Sci Soc Sci 73, 2018, 633). Alcohol consumption over the past 30 days measured with Form 30 was the strongest predictor of PEth levels for both middle-age and older adults, with age a small contributing predictor. General alcohol consumption patterns for amount of alcohol consumed over a 30-day period revealed middle-age adults consumed larger amounts of alcohol compared with older adults, but older adults consumed alcohol on more days than middle-age adults. Middle-age participants evidenced higher PEth levels than older adults at comparable drinking rates. Conclusions: Overall, findings suggest a strong relationship between alcohol consumption and PEth levels with age a small but contributing factor to predicting PEth levels.

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“…Because patients were recruited from only one hospital, the study might lead to selection bias. Although measurements of AD relapse through telephone interviews have been validated and used in some previous studies (Glass et al, 2017; Moos & Moos, 2006), they could be further validated in this Chinese patient group with the assistance of laboratory test indicators, such as serum ethanol concentration and carbohydrate-deficient transferrin (CDT) (Bortolotti et al, 2018). As the participants were all males, the findings of this study should not be generalized to female patients, although a recent review indicated that the relapse rate of AD was similar between genders (Petit et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

A real-world study on clinical predictors of relapse after hospitalized detoxification in a Chinese cohort with alcohol dependence

Tao

et al. 2019

PeerJ

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Background The relapse rate of alcohol dependence (AD) after detoxification is high, but few studies have investigated the clinical predictors of relapse after hospitalized detoxification in real-world clinical practice, especially among Chinese patients. Methods This longitudinal cohort study followed up 122 AD patients who were discharged from January 1, 2016 to January 30, 2018 from their most recent hospitalization for detoxification. These patients were interviewed by telephone from May 20, 2017, to June 30, 2018, at least 6 months after discharge. During the interview, the relapse were assessed by using a revised Chinese version of the Alcohol Use Disorder Identification Test. Candidate predictors, such as therapeutic modalities during hospitalization and at discharge, medical history data related to alcohol use, and demographic information, were obtained from the medical records in the hospital information system. Results During the 6–24 months (with a median of 9 months) follow-up period, the relapse rate was 53.3%. Individuals with a college education level and those who had not been treated with the brief comprehensive cognitive-motivational-behavioural intervention (CCMBI) were more likely than their counterparts to relapse after hospitalized detoxification, and their adjusted HRs (95% CIs) were 1.85 (1.09, 3.16) and 2.00 (1.16, 3.46), respectively. The CCMBI use predicted a reduction in the relapse rate by approximately one-fifth. Conclusion Undergoing the CCMBI during detoxification hospitalization and having less than a college-level education could predict a reduced risk of AD relapse. These findings provide useful information both for further clinical research and for real-world practice.

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Analytical and diagnostic aspects of carbohydrate deficient transferrin (CDT): A critical review over years 2007–2017

Cited by 50 publications

References 129 publications

Changes in the Human Metabolome Associated With Alcohol Use: A Review

Changes in the Human Metabolome Associated With Alcohol Use: A Review

Relationship of Phosphatidylethanol Biomarker to Self‐Reported Alcohol Drinking Patterns in Older and Middle‐Age Adults

A real-world study on clinical predictors of relapse after hospitalized detoxification in a Chinese cohort with alcohol dependence

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