Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities

Tschiche, Harald R.; Bierkandt, Frank S.; Creutzenberg, Otto; Fessard, Valérie; Franz, Roland; Greiner, Ralf; Gruber‐Traub, Carmen; Haas, Karl‐Heinz; Haase, Andrea; Hartwig, Andrea; Hesse, Bernhard; Hund‐Rinke, Kerstin; Iden, Pauline; Kromer, Charlotte; Löschner, Katrin; Mutz, Diana; Rakow, Anastasia; Rasmussen, Kirsten; Rauscher, Hubert; Richter, Hannes; Schoon, Janosch; Schmid, Otmar; Som, Claudia; Spindler, Lena Marie; Tovar, Günter E. M.; Westerhoff, Paul; Wohlleben, Wendel; Luch, Andreas; Laux, Peter

doi:10.1016/j.impact.2022.100416

Cited by 11 publications

(10 citation statements)

References 110 publications

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“…Also, there is a necessity for validated and standardised methods and tools for checking the risk assessment of nanomaterials in food. 44 Sprays, including cosmetics or cleaning products, pose potential inhalation exposure. Some studies link nanomaterial exposure from sprays to acute or chronic lung toxicity, airway inammation, or lung cell cytotoxicity.…”

Section: Nanomaterialsmentioning

confidence: 99%

“…The main limitation of the risk assessment is the dose metrics of the exposed nanoparticles due to the misuse of products. 44 In the medical sector, nanoparticles are widely used as a part of medical devices and pharmaceuticals. The nanoparticles are being used as visual prosthesis, cardiovascular stents, dental implants, osteosynthesis materials, and orthopaedic implants.…”

Section: Nanomaterialsmentioning

confidence: 99%

“…Also, there is a necessity for validated and standardised methods and tools for checking the risk assessment of nanomaterials in food. 44…”

Section: Nanomaterialsmentioning

confidence: 99%

“…The main limitation of the risk assessment is the dose metrics of the exposed nanoparticles due to the misuse of products. 44…”

Section: Nanomaterialsmentioning

confidence: 99%

See 3 more Smart Citations

The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles

Wojciechowska,

Costabile,

Kujawska

2023

Nanoscale Adv.

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Section: Nanomaterialsmentioning

confidence: 99%

Section: Nanomaterialsmentioning

confidence: 99%

See 2 more Smart Citations

The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles

Wojciechowska,

Costabile,

Kujawska

2023

Nanoscale Adv.

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“…Along with the rapid development of nanotechnology, various structural and functionalized nanomaterials (NMs) have emerged and are widely used in human society [ 1 , 2 ]. Nanotechnology is changing our lives, while engineered nanoparticles (ENPs) have become an environmental pollutant [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

Wang

2023

IJMS

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The assessment and prediction of the toxicity of engineered nanomaterials (NMs) present in mixtures is a challenging research issue. Herein, the toxicity of three advanced two-dimensional nanomaterials (TDNMs), in combination with an organic chemical (3,4-dichloroaniline, DCA) to two freshwater microalgae (Scenedesmus obliquus and Chlorella pyrenoidosa), was assessed and predicted not only from classical mixture theory but also from structure-activity relationships. The TDNMs included two layered double hydroxides (Mg-Al-LDH and Zn-Al-LDH) and a graphene nanoplatelet (GNP). The toxicity of DCA varied with the type and concentration of TDNMs, as well as the species. The combination of DCA and TDNMs exhibited additive, antagonistic, and synergistic effects. There is a linear relationship between the different levels (10, 50, and 90%) of effect concentrations and a Freundlich adsorption coefficient (KF) calculated by isotherm models and adsorption energy (Ea) obtained in molecular simulations, respectively. The prediction model incorporating both parameters KF and Ea had a higher predictive power for the combined toxicity than the classical mixture model. Our findings provide new insights for the development of strategies aimed at evaluating the ecotoxicological risk of NMs towards combined pollution situations.

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Nanoparticles as a younger member of the trace element species family — a food perspective

Gajdosechova,

Loeschner

2023

Anal Bioanal Chem

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Speciation analysis plays a key role in understanding the biological activity and toxicity of an element. So far, classical speciation analysis focused only on the dissolved fraction of an elemental species, whereas nanoparticle forms of analytes are being widely found in consumer and industrial products. A significant contributor to human exposure to nanoparticles is through food into which nanoparticles can be incorporated from endogenous sources or they may be formed naturally in the living organisms. Nanoparticles often undergo changes in the food matrices and upon consumption, in the gastrointestinal tract, which present a significant challenge to their characterisation. Therefore, a combination of both classical and nanoparticle speciation analytical techniques is needed for the characterisation of both dissolved and particulate forms of the chemical species. This article presents and discusses the current trends in analysis of nanoparticle behaviour in the gastrointestinal tract and formation and characterisation of biogenic nanoparticles. Graphical Abstract

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Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities

Cited by 11 publications

References 110 publications

The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles

The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

Nanoparticles as a younger member of the trace element species family — a food perspective

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