Analytical aspects of drugs of natural origin

Hamburger, Matthias; Hostettmann, Kurt

doi:10.1016/0731-7085(89)80139-6

Cited by 13 publications

(2 citation statements)

References 15 publications

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“…The analysis of natural compounds presents major challenges due to the great variety and reactivity of these compounds [25,26]. The analysis is facilitated by using modern separation and detection methods, such as hyphenated techniques of HPLC with MS, UV/Vis, or NMR spectroscopy.…”

Section: Analytical Methods In Research Of Natural Compoundsmentioning

confidence: 99%

Natural Products in the Process of Finding New Drug Candidates

Vuorela¹,

Leinonen²,

Saikku³

et al. 2004

CMC

282

187

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Natural derived or originated compounds still play a major role as drugs, and as lead structures for the development of synthetic molecules. About 50% of the drugs introduced to the market during the last 20 years are derived directly or indirectly from small biogenic molecules. In the future, natural products will continue to play a major role as active substances, model molecules for the discovery and validation of drug targets. A multidisciplinary approach to drug discovery involving the generation of truly novel molecular diversity from natural product sources, combined with total and combinatorial synthetic methodologies provides the best solution to increase the productivity in drug discovery and development. Screening for new drugs in plants implies the screening of extracts for the presence of novel compounds and an investigation of their biological activities. It is currently estimated that approximately 420,000 plant species exist in nature. For the purpose of lead discovery, or for the scientific validation of a traditional medicinal plant or a phytopharmaceutical, active principals in complex matrices need to be identified. Therefore, the interfacing of biological and chemical assessment becomes the critical issue. Drug discovery from plants can be guided by epidemiologic studies facilitated with computer assisted HPLC microfractionation and microplate technology. Epidemiologic studies have shown that high dietary flavonoid intake may be associated with decreased risk for cardiovascular disease. Chlamydia pneumoniae is a common human pathogen and epidemiological and clinical studies have shown a connection between chronic C. pneumoniae infection, atherosclerosis and the risk of myocardial infarction. We will present here the detection of natural compounds active against C. pneumoniae as an example.

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Section: Analytical Methods In Research Of Natural Compoundsmentioning

confidence: 99%

Natural Products in the Process of Finding New Drug Candidates

Vuorela¹,

Leinonen²,

Saikku³

et al. 2004

CMC

282

187

View full text Add to dashboard Cite

show abstract

“…For instance, Radix Ginseng, well reputed in TCM circles, is a prime example in which the whole plant or its saponin fractions are more active than the isolated compounds (Hamburger and Hostettman 1989 ). As TCM and network pharmacology continue to join efforts toward cataloguing herbal compounds and designing an international platform of standardization, herbal medicines will be more acceptable to empirical review parameters of clinical study.…”

Section: Contemporary Applications Of Tcm Herbs In Clinical Pharmacolmentioning

confidence: 99%

Traditional Chinese Medicine and Clinical Pharmacology

Marshall¹

2020

Drug Discovery and Evaluation: Methods in Clinical Pharmacology

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Traditional Chinese Medicine (TCM) represents thousands of years in treatment protocols for health, healing, and longevity and has evolved into a complex healthcare system. The following chapter is designed to give a basic concise overview of TCM principles and practices, in relation to clinical pharmacology, and focuses on mutually relevant areas of interest. Much as society learned to harness electrical currents to empower machinery, TCM theories of energetic patterns help to empower the functionality of the human body. The major theories include the vital life force, known as Qi, Yin and Yang, Five Elements, herbal medicine, multivariate diagnostics, syndrome differentiation, and acupuncture, among others. In TCM, there is a direct relationship o the energy of nature and the energetic patterns within the human body and the human consciousness. This comprehensive approach is gaining momentum in clinical and network pharmacology, as new technologies emerge regarding TCM collaborative compounds versus singular chemical constituents in treatment modalities. Of major importance to clinical pharmacology are recent TCM evidenced-based empirical studies, correlations, and interactions between herbs and pharmaceuticals, updated data on toxicity, adverse reactions, quality assurance, and herbal medicine standardization. Global concerns over antimicrobial resistance to drugs have put a spotlight on TCM herbal medicines as alternatives with greatly reduced resistance factors. From ancient archives to the Nobel Prize to a formal endorsement by the World Health Organization as a global healthcare system, TCM has widened the lens of modern science. It offers the wisdom and experience of millennia to inspire the think tank of today’s medicine and pharmacology and tomorrow’s generations of integrative healthcare advancements.

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Echinacea angustifolia

Ross¹

2001

Medicinal Plants of the World

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Analytical aspects of drugs of natural origin

Cited by 13 publications

References 15 publications

Natural Products in the Process of Finding New Drug Candidates

Natural Products in the Process of Finding New Drug Candidates

Traditional Chinese Medicine and Clinical Pharmacology

Echinacea angustifolia

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