Analytical aspects of printed oral dosage forms

Jacobsen, Jette Bredahl; Rantanen, Jukka; Rantanen, Jukka; Edinger, Magnus

doi:10.1016/j.ijpharm.2018.10.030

Cited by 36 publications

(16 citation statements)

References 84 publications

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“…While it is easy to conduct API content analysis using well-established methods such as UV spectroscopy and HPLC analysis, these methods require the use of destructive sample preparation that is costly. Therefore, the API content analysis of the printed dosage forms should ideally be conducted using non-destructive, robust and fast methods (5). This is especially important in the future to realize on-demand and near the end-users pharmacoprinting of personalized medicine (6) or to integrate it in a continuous manufacturing setup (7,8) according to the emerging regulatory framework (9).…”

Section: Introductionmentioning

confidence: 99%

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

et al. 2019

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“…Especially for poorly soluble drugs, the composition of drug-loaded fluid should avoid the drug sedimentation which is the main cause of dose inaccuracy but should maintain the viscosity in a range acceptable for printing [108]. Moreover, several parameters (e.g., evaporation time, droplet size formation) have to be set-up to print homogenously the drug onto the subtract [117].…”

Section: D Printingmentioning

confidence: 99%

Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

et al. 2020

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Medication adherence is a growing concern for public health and poor adherence to therapy has been associated with poor health outcomes and higher costs for patients. Interventions for improving adherence need to consider the characteristics of the individual therapeutic regimens according to the needs of the patients. In particular, geriatric and paediatric populations as well as dermatological patients have special needs/preferences that should be considered when designing drug products. Patient Centric Drug Product Pharmaceutical Design (PCDPD) offers the opportunity to meet the needs and preferences of patients. Packaging, orodispersible formulations, fixed dose combinations products, multiparticulate formulations, topical formulations and 3D printing are of particular relevance in a PCDPD process. These will be addressed in this review as well as their impact on medication adherence.

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“…Therefore, dose verification prior to drug administration was considered a prerequisite. Colorimetric and spectroscopic techniques for the analysis of drug content in printed dosage forms are proposed methods for nondestructive quality control permitting real-time batch release [36,37]. For on-demand manufacturing purposes, either handheld, user-friendly analytical devices that are quick to operate or devices that are automated and integrated to the printers have to be incorporated to the production process in order to enable quick response times in hospital pharmacies.…”

Section: Main Findingsmentioning

confidence: 99%

Benefits and Prerequisites Associated with the Adoption of Oral 3D-Printed Medicines for Pediatric Patients: A Focus Group Study among Healthcare Professionals

et al. 2020

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The utilization of three-dimensional (3D) printing technologies as innovative manufacturing methods for drug products has recently gained growing interest. From a technological viewpoint, proof-of-concept on the performance of different printing methods already exist, followed by visions about future applications in hospital or community pharmacies. The main objective of this study was to investigate the perceptions of healthcare professionals in a tertiary university hospital about oral 3D-printed medicines for pediatric patients by means of focus group discussions. In general, the healthcare professionals considered many positive aspects and opportunities in 3D printing of pharmaceuticals. A precise dose as well as personalized doses and dosage forms were some of the advantages mentioned by the participants. Especially in cases of polypharmacy, incorporating several drug substances into one product to produce a polypill, personalized regarding both the combination of drug substances and the doses, would benefit drug treatments of several medical conditions and would improve adherence to medications. In addition to the positive aspects, concerns and prerequisites for the adoption of 3D printing technologies at hospital settings were also expressed. These perspectives are suggested by the authors to be focus points for future research on personalized 3D-printed drug products.

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Analytical aspects of printed oral dosage forms

Cited by 36 publications

References 84 publications

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy

Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

Benefits and Prerequisites Associated with the Adoption of Oral 3D-Printed Medicines for Pediatric Patients: A Focus Group Study among Healthcare Professionals

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