This paper presents a synoptic (“Two-Eyed Seeing”) approach to science transfer in Education for Sustainable Development (ESD), based on an ontological framework inspired by two related concepts from Western philosophy (Sellars’ synoptic view) and indigenous wisdom (Two-Eyed Seeing). It was tested and further developed in a participatory research process with first year student science teachers. The results show that this model can support a balanced approach between a scientific and a holistic perspective at each stage of the teaching process—preparation, implementation and assessment—and help to integrate sustainability issues consistently into science lessons. In the course of the research process, the model has developed into a viable educational tool that distinguishes between a person-oriented lifeworld image and a things-oriented scientific image and guides the systematic transfer between the two images. It promotes students’ reasoning and scientific practice as well as their identity formation and community interaction, two equally important issues in ESD of today. The pre-service teachers were careful to close the loop, as they put it, between the two images. They saw health and environmental issues as particularly helpful in realising scientific holism. The pre-service teachers interpreted the role of the teacher as a facilitator or mediator between the two images rather than as an expert and advocate of a one-sided scientific image of the world. The model may be of general interest to teachers and researchers who design, implement, evaluate and investigate ESD activities. The potential use of the scientific holism framework and the synoptic (“Two-Eyed Seeing”) tool for science transfer in public and political sustainability discourse is also discussed.