Analytical Control of a Starter Pig Feed Medicated with Amoxicillin

Zemanová, Martina; Maxa, J; Hera, Alfréd; Haas, Z.; Lemaire, F.; Sanquer, A.; Bousquet, E.

doi:10.2754/avb200877030341

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“…administration; and 4–8 mg·kg -1 b.w. for APR (Apralan G + 200 Premix) [ 17 ]. In the present study, we formulated the dosage of GRANULE amo + apr as 16 mg and 4 mg per kg b.w., which is consistent with the recommended dosage of Commission of Chinese Veterinary Pharmacopoeia [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs

et al. 2017

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A new compound granular premix of amoxicillin (20% w/w dry mass)/apramycin (5% w/w dry mass) was developed, and its pharmacokinetics and relative bioavailability were determined in pigs following oral administration following a cross-over study design. The pharmacokinetic parameters of amoxicillin (t1/2λ = 6.43 ± 4.85h, Cmax = 3.2 ± 1.35 μg·mL-1, Tmax = 1.92 ± 0.58, AUCINF = 8.98 ± 2.11 h·μg·mL-1) and apramycin (t1/2λ = 8.67±4.4h, Cmax = 0.23 ± 0.12 μg·mL-1, Tmax = 2.25 ± 0.82 h, AUCINF = 12.37 ± 8.64h·μg·mL-1) when administered as the amoxicillin-apramycin granular premix did not significantly differ from those for the single-ingredient powder form of each component. The relative bioavailability of amoxicillin following oral administration of the amoxicillin-apramycin granular premix was 22.62% when compared to the intramuscular administration of commercial amoxicillin sodium-powder. This is the first report of a new amoxicillin-apramycin combination which has a potential veterinary application the for prevention and treatment digestive tract infections in pigs.

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Section: Discussionmentioning

confidence: 99%