Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients

Siahi, Mohammad Reaz; Rahimi, Soma; Monajjemzadeh, Farnaz

doi:10.15171/apb.2018.074

Cited by 11 publications

(4 citation statements)

References 24 publications

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“…The second endothermic process at 210 ºC corresponds to a fusion/melting temperature of dextrose (33,34).…”

Section: Resultsmentioning

confidence: 99%

Characterization of Potassium Nitrate/Dextrose Solid Rocket Propellant Using Calorimetry

Lopez-Telgie,

Murcia Piñeros,

Morales-Verdejo

2023

J. Chil. Chem. Soc.

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The use of the Potassium Nitrate as an oxidizer in solid rocket propellants has been common in recent years for experimental research in solid rocket propulsion systems. This chemical is used as a compound of black powder and explosives, but in the last 30 years, it has been studied for applications in semiprofessional rocket propellant, implemented by Universities in research and academic projects. The Potassium Nitrate/Dextrose propellant is also known as Candy propellant and presents some advantages compared with other solid propellants. They are low production costs and ease of acquisition for the chemical components. These advantages are attractive for low-cost projects, compared to the low performance; this does not discourage its use.The Candy propellant presented a lack of experimental data to characterize, for example, its thermal properties. For this reason, were used the Differential Scanning Calorimetry and the Semi-Micro Calorimetry tests, to obtain the heat of combustion, power, and temperatures of melting and ignition. The grains of Candy propellant were manufactured at the University of Conception by the Propulsion Interest Team. This is the first time which is reported the calorimetric data of the Candy propellant (Potassium Nitrate/Dextrose). The results in this work presented a heat combustion in the range 523 -567 Cal•g −1 , decomposition temperature in the range 356 -361 °C and a heat released in the range 1080 -1809 J•g −1 of the mixture KNO3/Dextrose, which contribute to the professional characterization of the propellant.

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“…The second endothermic process at 210 ºC corresponds to a fusion/melting temperature of dextrose (33,34).…”

Section: Resultsmentioning

confidence: 99%

Characterization of Potassium Nitrate/Dextrose Solid Rocket Propellant Using Calorimetry

Lopez-Telgie,

Murcia Piñeros,

Morales-Verdejo

2023

J. Chil. Chem. Soc.

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“…In Figure 1 the pathways and possible interaction were shown. 12 The process suggested by Szalka et al, 13 was used to create N-formyl leucine. DMF was used to dissolve the drug, and it was refluxed for two days at 150 °C.…”

Section: N-formyl Leucine Synthesismentioning

confidence: 99%

Detection of Excipient–Excipient Interaction in Dry Powder Inhaler Formulation Prepared by Spray Drying

Gholizadeh-Hashjin,

Hamishehkar,

Monajjemzadeh

2024

Pharm Sci

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Background: Dry powder inhalers (DPIs) are dosage forms that are used via the pulmonary route. Their formulations include two major parts; drug substance and carrier. For many years, DPIs have been made with lactose, a particularly popular carrier. Leucine has drawn more attention in recent years when it comes to DPI formulations made using the spray drying technique. Leucine was utilized in conjunction with carriers like lactose to enhance physicochemical and aerosolization properties. Method: In this investigation, when lactose and leucine were co-spray dried, the color of powders around the cyclone separators of the spray dryer turned brown while the produced powder in the collector was white. Both the white powder inside the collector and the brown powder around the cyclone separators were investigated by differential scanning calorimetry (DSC), Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), x-ray diffraction (XRD), and liquid chromatography with tandem mass spectrometry (LC-MS-MS) to determine the identity of the degraded chemicals and to look for any potential interactions. Results: A new peak at 177 ºC in DSC analysis is a sign of interaction. Also, FT-IR analysis shows the new peak at 1627 cm-1 which is related to the carbonyl group. According to SEM and XRD analysis co spray dried leucine-lactose is amorphous. Obtained data from LC-MS analysis indicates the adduct compound of leucine-lactose that resulted from the Maillard reaction was detected in both white and brown powder. Also, the reaction proceeded to form n-formyl compound. Conclusion: There is a possibility of lactose and leucine incompatibility during DPIs manufacturing, especially in elevated temperature and humidity.

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“…Methyldopa is a medication commonly used to treat hypertension in addition to an anti-Parkinson agent [1] and has been used since the 1960s [2]. It is available under the brand name Aldomet [3].…”

Section: Methyldopamentioning

confidence: 99%

The Impact of the Drug Methyldopa in Both Medical and Industrial Applications

Naoom¹,

Yousif²,

Salman³

et al. 2022

ANJS

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Methyldopa is a medication usually used to regulate and treat hypertension. It is one of the most commonly used therapies for high blood pressure during pregnancy. Methyldopa acts on blood vessels by providing additional relaxation, therefor blood can flow more easily through the body. Also, Methyldopa is a common medication used during pregnancy and is unlikely to cause any risk to the baby.

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Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients

Cited by 11 publications

References 24 publications

Characterization of Potassium Nitrate/Dextrose Solid Rocket Propellant Using Calorimetry

Characterization of Potassium Nitrate/Dextrose Solid Rocket Propellant Using Calorimetry

Detection of Excipient–Excipient Interaction in Dry Powder Inhaler Formulation Prepared by Spray Drying

The Impact of the Drug Methyldopa in Both Medical and Industrial Applications

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