Analytical Method Volume Intensity (AMVI): A green chemistry metric for HPLC methodology in the pharmaceutical industry

Hartman, Robert; Helmy, Roy; Al‐Sayah, Mohammad A.; Welch, Christopher J.

doi:10.1039/c0gc00524j

Cited by 116 publications

(30 citation statements)

References 16 publications

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“…Such tools are valuable when choosing and developing analytical methods, in this case, regarding the selection of solvents for HPLC methods. In a similar study, an analytical method volume intensity (AMVI) green metrics tool for HPLC methods was developed, simply based on the total solvent consumption per chromatographic peak of interest [59]. In this case, no value was put on what type of solvent was used, but rather just the volume.…”

Section: Green Metricsmentioning

confidence: 99%

Sustainable analytical chemistry—more than just being green

Turner

2013

Pure and Applied Chemistry

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This review article describes analytical chemistry beyond green chemistry and all efforts that contribute to a more sustainable development. A background is given on sustainable development and green chemistry. Examples of "greening" strategies for sample preparation, chromatography, and detection are given. Thereafter, the review discusses how and why a method or a solvent could be claimed as being "green". Green metrics for analytical chemistry is discussed, including the environment, health, and safety (EHS) index and life cycle assessment (LCA). The choice of solvent and the criteria for a solvent being "green" is also discussed. Finally, sustainable analytical chemistry is described by considering the three important "legs" so as to obtain sustainable development-economic feasibility, societal relevance, and environmental soundness. Hopefully, the review article will stimulate some new perspectives on the difference between greenness and sustainability in analytical chemistry.

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Section: Green Metricsmentioning

confidence: 99%

Sustainable analytical chemistry—more than just being green

Turner

2013

Pure and Applied Chemistry

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“…Several research, education, and outreach programs were adopted as central themes [4]. Over the years, green chemistry was able to demonstrate how fundamental scientific methodologies can protect human health and the environment in an economically beneficial manner incorporating areas such as polymers [5], solvents [6], catalysis [7], analytical method development [8], synthetic methodology development [9] and, in general, the design of safer chemicals with an increased awareness for environmental impact. In this context, biomass and renewable raw materials are at the basis of the alignment of many industrial applications to the principles of green chemistry and sustainability.…”

Section: Introductionmentioning

confidence: 99%

Green Corrosion Inhibitors from Natural Sources and Biomass Wastes

2018

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Over the past decade, green chemistry has been emphasizing the importance of protecting the environment and human health in an economically beneficial manner aiming at avoiding toxins and reducing wastes. The field of metallic materials degradation, generally faced by using toxic compounds, found a fertile research field in green chemistry. In fact, the use of inhibitors is a well-known strategy when metal corrosion needs to be prevented, controlled, or retarded. Green inhibitors are biodegradable, ecologically acceptable and renewable. Their valorization expands possible applications in industrial fields other than ‘waste to energy’ in the perspective of circular economy. Although lot of experimental work has been done and many research papers have been published, the topic of green inhibitors is still an open issue. The great interest in the field expanded the research, resulting in high numbers of tested molecules. However, the most frequently adopted approaches are conventional and, hence, not suitable to fully characterize the potential efficacy of inhibitors. All the mentioned aspects are the object of the present review and are meant as a constructive criticism to highlight the weak points of the green inhibitors field as to re-evaluate the literature and address the future research in the field that still lacks rationalization.

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“…Herein, the aqueous and organic modifier consumed starting from sample preparation step to letter in HPLC mobile phase were calculated and these values were entered into the software to get the final EAT score. AMVI (total solvent consumption) was calculated as per the equation 4 given by Hartman et al 3 AMVI gives the total amount of solvent consumed in the HPLC method. For the purpose of comparison, the method developed on Thermo 150×4.6 mm GAC column was also applied to Waters 250×4.6 mm column.…”

Section: Green Metrics Assessmentmentioning

confidence: 99%

“…1 The green metrics assessment includes EAT (Environment assessment tool), AMVI (Analytical method volume intensity) and treatment option score given by the Ecosolvent ® tool. [2][3] The EAT tool considers all three aspects of Environment, health and safety and gives the score for same. 2 The lower EAT score indicates an environment friendly method.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of an Environmentally Benign and Robust Stability Indicating Assay Method for Lenalidomide: Comprehensive Degradation Kinetics Study and Application of Synergistic Approach Involving Green Analytical Chemistry and Quality by Des

Saxena¹,

Saroj²,

Shah³

et al. 2019

IJPER

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Objective: A state of the art, robust and environmentally benign stability indicating assay method (SIAM) has been developed for model drug Lenalidomide (LEN). Methods: A Green metrics assessment was conducted by environment assessment tool (EAT), analytical method volume intensity (AMVI) and Ecosolvent ® tool. Successful chromatographic separation was accomplished on a Thermo C18 GAC column having dimensions of 4.6×150 mm and 3µ particle size using green solvents viz., methanol and acetate buffer in the ratio of 85:15. Results: The obtained EAT score and AMVI were 32.19 and 24 mL respectively. A green SIAM was developed and it was validated as per ICH Q2 (R1) guidelines. Quality by Design (QbD) approach was incorporated at validation stage to prove the robustness of the developed green method by applying 2^5-2 Res III 2-level fractional factorial design (FFD). Conclusion: An extensive stress degradation study along with degradation kinetics were performed and probable degradation pathways were predicted.

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Analytical Method Volume Intensity (AMVI): A green chemistry metric for HPLC methodology in the pharmaceutical industry

Cited by 116 publications

References 16 publications

Sustainable analytical chemistry—more than just being green

Sustainable analytical chemistry—more than just being green

Green Corrosion Inhibitors from Natural Sources and Biomass Wastes

Development and Validation of an Environmentally Benign and Robust Stability Indicating Assay Method for Lenalidomide: Comprehensive Degradation Kinetics Study and Application of Synergistic Approach Involving Green Analytical Chemistry and Quality by Des

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Analytical Method Volume Intensity (AMVI): A green chemistry metric for HPLC methodology in the pharmaceutical industry

Cited by 116 publications

References 16 publications

Sustainable analytical chemistry&mdash;more than just being green

Sustainable analytical chemistry&mdash;more than just being green

Green Corrosion Inhibitors from Natural Sources and Biomass Wastes

Development and Validation of an Environmentally Benign and Robust Stability Indicating Assay Method for Lenalidomide: Comprehensive Degradation Kinetics Study and Application of Synergistic Approach Involving Green Analytical Chemistry and Quality by Des

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Product

Resources

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Sustainable analytical chemistry—more than just being green

Sustainable analytical chemistry—more than just being green