Analytical methodologies for determination of artificial sweeteners in foodstuffs

Zygler, Agata; Wasik, Andrzej; Namieśnik, Jacek

doi:10.1016/j.trac.2009.06.008

Cited by 143 publications

(108 citation statements)

References 120 publications

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“…Common types of artificial sweeteners include aspartame, acesulfame-K, cyclamate, neotame, sucralose, and saccharin. [10] Although artificial sweeteners have been welcomed into the food industry for its beneficial uses, some studies have found correlations between their use and illnesses such as cancers, hepatotoxicity, headaches, allergies, seizures, diarrhoea, and low birth weight. [9] Commercially available saccharin is almost 300-500 times sweeter than sucrose.…”

Section: Introductionmentioning

confidence: 99%

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THEIN VITROEFFECTS OF ARTIFICIAL AND NATURAL SWEETENERS ON THE IMMUNE SYSTEM USING WHOLE BLOOD CULTURE ASSAYS

Rahiman

Pool

2013

Journal of Immunoassay and Immunochemistry

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. The in vitro effects of artificial and natural sweeteners on the immune system using whole blood culture assays. The in vitro effects of artificial and natural sweeteners on the immune system using whole blood culture assays F. Rahiman and E. J. Pool AbstractThis article investigates the effects of commercially available artificial (aspartame, saccharin, sucralose) and natural sweeteners (brown sugar, white sugar, molasses) on the immune system. Human whole blood cultures were incubated with various sweeteners and stimulated in vitro with either phytohemagglutinin or endotoxin. Harvested supernatants were screened for cytotoxicity and cytokine release.

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Section: Introductionmentioning

confidence: 99%

“…Hence, sucralose has also been subjected to toxicity screening. [10] Since their existence, the usage of natural and artificial sweeteners has been quite controversial. Their implication in various diseases has raised much questionability with respect to their safe use.…”

Section: Introductionmentioning

confidence: 99%

THEIN VITROEFFECTS OF ARTIFICIAL AND NATURAL SWEETENERS ON THE IMMUNE SYSTEM USING WHOLE BLOOD CULTURE ASSAYS

Rahiman

Pool

2013

Journal of Immunoassay and Immunochemistry

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“…Furthermore, with product innovations and changing tastes among consumers, the concentrations of LCS within products are likely to evolve over time, potentially introducing error into subsequent estimates of exposure unless ongoing data are received from manufacturers. Another method for determining LCS concentrations in products is to directly measure them analytically and to this end, numerous methodologies for the determination of LCS in foods and beverages have been published (10) . Recent studies investigating LCS exposure have adopted this approach (50)(51)(52)(53)57,58) and, although it allows for a more accurate and objective measure of LCS concentrations in products, it is also likely to be costly.…”

Section: Methods Of Assessing Exposure To Low-calorie Sweetenersmentioning

confidence: 99%

The potential application of a biomarker approach for the investigation of low-calorie sweetener exposure

et al. 2016

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Low-calorie sweeteners (LCS) are commonly used as sugar substitutes in the diet to provide a desired sweet taste without increased energy intake. The number of LCS available on the market has increased considerably over the years and despite extensive evaluation of their safety prior to approval, debate continues around the effects of consumption on health. In Europe, Member States are obligated to monitor exposure to LCS and methods currently used tend to rely on self-reported dietary intake data alongside LCS concentrations in products. However, the acquisition of accurate data can be costly in terms of resources and time and are inherently imprecise. Although LCS are intensely sweet, they are chemically diverse and a limitation of many studies investigating the health effects of consumption is that they often fail to discern intakes of individual LCS. An approach which objectively assesses intakes of individual LCS would therefore allow robust investigations of their possible effects on health. Biomarker approaches have been utilised for the objective investigation of intakes of a range of dietary components and the feasibility of any such approach depends upon its validity as well as its applicability within the target population. This review aims to provide an overview of current understanding of LCS intake and explore the possibility of implementing a biomarker approach to enhance such understanding. Several commonly used LCS, once absorbed into the body, are excreted via the kidneys; therefore a urinary biomarker approach may be possible for the investigation of short-term exposure to these compounds.

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“…It has a sweetening strength about 450 times that of sucrose and exhibits high water solubility and storage stability [7]. In the 1980s, its consumption was linked with bladder cancer in rats and as such was prohibited in Canada [8].…”

Section: Introductionmentioning

confidence: 99%

“…Unlike SAC, DUL does not have a bitter aftertaste and has a sweetening capacity about 250 times that of ft sucrose. However, DUL has not gained widespread use due to concerns over its toxicity [7]. It is not approved for use in the USA.…”

Section: Introductionmentioning

confidence: 99%

Recent Analytical Methods for the Analysis of Sweeteners in Food: A Regulatory Perspective

Shah

Jager

2016

Food Safety

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Analytical methodologies for determination of artificial sweeteners in foodstuffs

Cited by 143 publications

References 120 publications

THEIN VITROEFFECTS OF ARTIFICIAL AND NATURAL SWEETENERS ON THE IMMUNE SYSTEM USING WHOLE BLOOD CULTURE ASSAYS

THEIN VITROEFFECTS OF ARTIFICIAL AND NATURAL SWEETENERS ON THE IMMUNE SYSTEM USING WHOLE BLOOD CULTURE ASSAYS

The potential application of a biomarker approach for the investigation of low-calorie sweetener exposure

Recent Analytical Methods for the Analysis of Sweeteners in Food: A Regulatory Perspective

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