Analytical Methodologies for the Determination of Midazolam in Pharmaceuticals

Espinosa-Bosch, M; Ruiz-Sánchez, Antonio J.; Rojas, F. Sánchez; Ojeda, C. Bosch

doi:10.1007/s10337-015-2885-z

Cited by 10 publications

(2 citation statements)

References 39 publications

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“…Pharmacies are also required to respond to therapeutic needs not covered by the pharmaceutical industry, as in the case of mixture off different drugs in the same recipient. In a previous work published by us there are a revision about the stability's studies of midazolam alone and in mixture with other drugs [17].…”

Section: Introductionmentioning

confidence: 99%

Stability of Binary Mixtures of Drugs at Different Concentrations and Temperatures

Fuensanta¹

2022

J Pharm Res Sci Technol

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Background and Objective: In order to avoid separate injections, admixtures of drugs are frequently used in palliative care setting. The objective of this work is to study the stability of binary mixtures of drugs (ondansetron and midazolam) at different concentrations and temperatures all prepared in 0.9% NaCl and stored into infusers and glass in all cases protected from light. Materials and Methods: Two methods have been employed to determine periodically the concentration of each drug in the mixtures (HPLC-UV and UV-vis spectrophotometry methods). The concentrations of the samples were: 0.1 mg mL-1 – 0.1 mg mL-1 and 0.5 mg mL-1 – 1.0 mg mL-1 of ondansetron and midazolam respectively; temperature of storage 25ºC and 37ºC. NaCl 0.9% was used as diluent in all cases. The containers to store each mixture were three infusers and glass. Results: All solutions were initially clear and colourless but visible particles appear, in all cases, into the infusers after two days since their preparation. Conclusions: The admixture of ondansetron and midazolam in NaCl 0.9% is recommended to use for a maximum of one day, at the concentrations evaluated, over time it tends to precipitate. Infuser conditioning decreases stability with respect to other conditions materials, so other stability studies may not be extrapolated if stored under different conditions.

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Section: Introductionmentioning

confidence: 99%

Stability of Binary Mixtures of Drugs at Different Concentrations and Temperatures

Fuensanta¹

2022

J Pharm Res Sci Technol

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“…2,8,10 The quality control assessment of this drug in pharmaceutical formulations and biological samples is required due to its widespread and worldwide commercialization. Different analytical methods have been used such as HPLC with coulometric detection, 13 liquid chromatography-mass spectrometry, 14 thin layer chromatography, capillary electrophoresis, 15 UV-spectrophotometry, 16 etc. These methods show some drawbacks like high cost, complicated and timeconsuming process, contamination, and high detection limits.…”

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New Insight in Fabrication of a Sensitive Nano-Magnetite/Glutamine/Carbon Based Electrochemical Sensor for Determination of Aspirin and Omeprazole

Atta

El-Ads

Galal

2019

J. Electrochem. Soc.

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In the present study, we introduce a direct and sensitive voltammetry approach for the simultaneous determination of aspirin (ASA) and omeprazole (OMZ) for patients suffering from cardiovascular diseases and gastrointestinal disorders. Low dose of ASA can be used for the prevention of cardiovascular diseases which is considered the most severe cause of mortality worldwide. On the other hand, OMZ can reduce the risk of gastric ulcers and gastrointestinal damage associated with ASA. The used electrode was constructed by in situ-modification with multi-walled carbon nanotubes, glutamine, and nano-magnetite in presence of sodium dodecyl sulfate (FeGluCNTCP-SDS). Using this sensor, the limits of detection were 11.9 nmol•L −1 and 3.3 nmol•L −1 for ASA and OMZ, respectively. The proposed sensor was used for the determination of OMZ in presence of dopamine, paracetamol, ascorbic acid, and uric acid without noticeable interference in their binary or ternary mixtures. The proposed surface showed good analytical performance toward OMZ determination and has a promising application for the electrochemical sensing of other drugs of pharmaceutical importance.

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Polymer-Grafted Nanographite Support Obtained Using Iminodiacetic Acid/Allyl Glycidyl Ether: Characterization and Application in the Extraction and Determination of Enrofloxacin in Biological and Pharmaceutical Samples

Panahi

Alimadadi

2015

Chromatographia

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Analytical Methodologies for the Determination of Midazolam in Pharmaceuticals

Cited by 10 publications

References 39 publications

Stability of Binary Mixtures of Drugs at Different Concentrations and Temperatures

Stability of Binary Mixtures of Drugs at Different Concentrations and Temperatures

New Insight in Fabrication of a Sensitive Nano-Magnetite/Glutamine/Carbon Based Electrochemical Sensor for Determination of Aspirin and Omeprazole

Polymer-Grafted Nanographite Support Obtained Using Iminodiacetic Acid/Allyl Glycidyl Ether: Characterization and Application in the Extraction and Determination of Enrofloxacin in Biological and Pharmaceutical Samples

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