Analytical methods for mixed organic chemical residues and contaminants in food

Turnipseed, Sherri B; Jayasuriya, Hiranthi

doi:10.1007/s00216-020-02668-8

Cited by 19 publications

(10 citation statements)

References 57 publications

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“…With respect to the latter, one major advantage of HRMS is based on their easy adaption for non-targeted analysis, which opens possibilities for unexpected findings. In addition, retrospective analysis enables the identification of additional metabolites and transformation products which can provide distinct information on the influence of changing climate conditions to the occurrence of natural contaminants, such as mycotoxins [21]. However, traditional quantitative approaches based on HRMS are difficult to compare, but each mass analyzer (Orbitrap and TOF) has its specific merits.…”

Section: Feasibility Of Multiclass Methodsmentioning

confidence: 99%

“…However, the first comprehensive method combining several substance classes within one analytical procedure was designed by Mol et al in the year 2008 [20]. Since then, the number of so-called multiclass methods has increased considerably, as a comprehensive overview by Turnipseed and Jayasuriya has recently revealed [21]. Selected LC-MS-based multiclass applications for food and feed are provided in Table 2.…”

Section: Multi-analyte Approaches: An Overviewmentioning

confidence: 99%

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Challenges and future directions in LC-MS-based multiclass method development for the quantification of food contaminants

Steiner¹,

Malachová²,

Sulyok

et al. 2020

Anal Bioanal Chem

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Monitoring of food contaminants and residues has undergone a significant improvement in recent years and is now performed in an intensive manner. Achievements in the area of chromatography-mass spectrometry coupling techniques enabled the development of quantitative multi-target approaches covering several hundred analytes. Although the majority of methods are focusing on the analysis of one specific group of substances, such as pesticides, mycotoxins, or veterinary drugs, current trends are going towards the simultaneous determination of multiclass compounds from several families of contaminants and residues. This work provides an overview of relevant multiclass concepts based on LC-MS/MS and LC-HRMS instruments. Merits and shortcomings will be critically discussed based on current performance characteristics of the EU legislation system. In addition, the discussion of a recently developed multiclass approach covering >1000 substances is presented as a case study to illustrate the current developments in this area.

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Section: Feasibility Of Multiclass Methodsmentioning

confidence: 99%

Section: Multi-analyte Approaches: An Overviewmentioning

confidence: 99%

Challenges and future directions in LC-MS-based multiclass method development for the quantification of food contaminants

Steiner¹,

Malachová²,

Sulyok

et al. 2020

Anal Bioanal Chem

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show abstract

“…However, a current trend in monitoring food for chemical residues and contaminants is to combine as many analytes as possible into a single method with an emphasis on developing laboratory methods which simultaneously analyse compounds from multiple categories including pesticides, veterinary drugs, mycotoxins, and other organic chemicals in a variety of food commodities (Turnipseed and Jayasuriya, 2020). A review describes several methods developed for simultaneous analysis of veterinary drugs and pesticide residues (Garrido Frenich et al, 2014. Improvements in instrumentation and in data processing software, for both liquid chromatographymass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS), have facilitated the ability to quickly query the mass data for hundreds of analytes in an automated manner and to find out unexpected analytes.…”

Section: Regulation On Residuesmentioning

confidence: 99%

Section: Description Of Work Programmementioning

confidence: 99%

Study of the different evaluation areas in the pesticide risk assessment process

Molteni¹,

Alonso-Prados²

2020

EFS2

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Approval of active substances and authorisation of plant protection products in the EU is made based on a strict risk assessment of the agronomic use of the plant protection products. Regulation 1107/2009 regulates the procedure in the EU with complex procedures involving many actors. 'The Farm to Fork strategy' and 'The Biodiversity for 2030 strategy', that are the heart of the 'European Green Deal', aiming to make food systems fair, healthy, environmentally friendly and put Europe's biodiversity on the path to recovery by 2030, for the benefit of people, climate and the planet. Therefore, 'The Farm to Fork strategy' and 'The Biodiversity for 2030 strategy' represents a challenge for the evaluation and authorisation of plant protection products in which the risk management will constitute a key element on the approval of active substances and authorisation of plant protection products. The aim of the work was to get knowledge of the large body of EU legislation and guidelines in the plant production products, identifying the most critical points of the pesticide evaluation in each of its areas, analysing the complexity and the interaction between these different areas. This study allowed to have a global and clearer vision of these procedures, with the focus on highlighting inconsistency and to propose speed up alternatives. Finally, this work will also facilitate not only the risk assessment but also the decision-making on the approval of active substances and the authorisation of plant protection products.

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“…[1] Therefore, there have been many methods reported to detect different contaminants in various foods; the most commonly used techniques are chromatographical methods and immunochemical methods. [2,3] Among the reported methods, immunochemical methods, including enzyme-linked immunosorbent assay, [3] chemiluminescence immunoassay, [4] and chemiluminescence resonance energy transfer immunoassay, [5] are usually used to analyze large numbers of samples due to their high-throughput analysis ability. Immunoassays based on colorimetry and (chemi)luminescence usually require an enzymelabelled competitor and a substrate to generate the signal.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of molecularly imprinted microspheres and development of a fluorescence method for detection of chloramphenicol in meat

et al. 2021

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In this study, nitrobenzene was used as dummy template to synthesize a type of specific molecularly imprinted microspheres for chloramphenicol, and 4-nitroaniline was coupled with three fluorophores to synthesize three fluorescent tracers. Then a competitive fluorescence method was developed on a conventional microplate for detection of chloramphenicol in chicken and pork samples. This method contained only one sample-loading step, so one assay was finished within 30 min. The IC 50 was 1.8 ng/ml, and the limit of detection was 0.06 ng/g. The recoveries from chloramphenicol-fortified blank meat samples were in the range 67.5-96.2%. Furthermore, this method could be recycled three times. The detection results for some real meat samples were identical to that of a LC-MS/MS method. Therefore, this method could be used as a practical tool for routine screening for the residue of chloramphenicol in large number of meat samples.

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Analytical methods for mixed organic chemical residues and contaminants in food

Cited by 19 publications

References 57 publications

Challenges and future directions in LC-MS-based multiclass method development for the quantification of food contaminants

Challenges and future directions in LC-MS-based multiclass method development for the quantification of food contaminants

Study of the different evaluation areas in the pesticide risk assessment process

Synthesis of molecularly imprinted microspheres and development of a fluorescence method for detection of chloramphenicol in meat

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