Analytical mitigation of solute–capillary interactions in double detection Taylor Dispersion Analysis

Methodologies for the rapid determination of the diffusion interaction parameter using Taylor dispersion analysis

“…D can then be estimated from eqn (14). This method shall be termed the explicit differentiation method.…”

“…The mutual diffusion coefficient of the injected solute can then be deduced by a variety of methods ranging from tting Taylor's solution to the concentration prole or taylorgram of the solute to the calculation of moments. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] Whilst there are numerous methods for the determination of intradiffusion (or self-diffusion) coefficients, Taylor dispersion analysis is one of a few methods 16,17 that can be used to determine mutual diffusion coefficients which are the appropriate measures for bulk ion transport. Although theoretical relationships between intradiffusion and mutual diffusion coefficients, these have met with limited success.…”

Inline Coupling of Electrokinetic Preconcentration Method to Taylor Dispersion Analysis for Size-Based Characterization of Low-UV-Absorbing Nanoparticles

“…For example, TDA can easily be disturbed by the presence of chromophoric compounds (e.g., UV-absorbing solvent, impurity) in the sample . Interactions between solutes and capillary walls can be detrimental for the results, and the capillary wall interactions must be minimized . Moreover, as is the case for the DLS, TDA gives the size of one diffusing ensemble.…”

“…For the mixture of solutes, or polydisperse samples, TDA leads to a harmonic weight-average diffusion coefficient . Recently, methodologies have been developed for the analysis of sample polydispersity , and for the analytical mitigation of solute–capillary wall interactions . Moreover, by applying an initial electrophoretic separation step prior to the application of the pressure, it is possible to perform individual diffusion coefficient measurements in a sample mixture. , …”

“…24 Interactions between solutes and capillary walls can be detrimental for the results, and the capillary wall interactions must be minimized. 36 Moreover, as is the case for the DLS, TDA gives the size of one diffusing ensemble. For the mixture of solutes, or polydisperse samples, TDA leads to a harmonic weight-average diffusion coefficient.…”