Analytical model of the dynamic behavior of a vibrating mesh nebulizer for optimal atomization efficiency

Fossat, Pascal; Ichchou, Mohamed; Bareille, Olivier

doi:10.1016/j.sna.2022.113646

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…The pore size can be adjusted according to the specific requirements. Upon ultrasonic vibration, the liquid is extruded, resulting in many droplets, which can be divided into active vibrating mesh nebulizers and passive vibrating mesh nebulizers [ 105 , 113 ]. Although vibrating mesh nebulizers are expensive and require regular maintenance and cleaning [ 114 , 115 ], we believe they are promising pulmonary delivery devices for clinical application.…”

Section: Various Inhalation Devices Are Used Clinicallymentioning

confidence: 99%

Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives

Peng,

Wang,

Zhang

et al. 2024

Pharmaceutics

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With the development of nanotechnology and confronting the problems of traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable nano-formulations for treating lung diseases allow for precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol lung deposition rates, and increasing drug bioavailability. They are expected to solve the difficulties faced in treating lung diseases. However, limited success has been recorded in the industrialization translation of inhalable nano-formulations. Only one relevant product has been approved by the FDA to date, suggesting that there are still many issues to be resolved in the clinical application of inhalable nano-formulations. These systems are characterized by a dependence on inhalation devices, while the adaptability of device formulation is still inconclusive, which is the most important issue impeding translational research. In this review, we categorized various inhalable nano-formulations, summarized the advantages of inhalable nano-formulations over conventional inhalation formulations, and listed the inhalable nano-formulations undergoing clinical studies. We focused on the influence of inhalation devices on nano-formulations and analyzed their adaptability. After extensive analysis of the drug delivery mechanisms, technical processes, and limitations of different inhalation devices, we concluded that vibrating mesh nebulizers might be most suitable for delivering inhalable nano-formulations, and related examples were introduced to validate our view. Finally, we presented the challenges and outlook for future development. We anticipate providing an informative reference for the field.

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Section: Various Inhalation Devices Are Used Clinicallymentioning

confidence: 99%

Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives

Peng,

Wang,

Zhang

et al. 2024

Pharmaceutics

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“…A fast atomization rate is achievable through high-frequency vibration and the patterning of multiple pinholes on the membrane. Furthermore, power demand is very low because energy is directly transferred to the vibration parts [28,29]. Therefore, vibrating mesh-type piezoelectric atomizers have been widely used for humidification, drug delivery, and spray cooling [30,31].…”

Section: Introductionmentioning

confidence: 99%

A vibrating membrane ejector for direct ink writing of printed electronics

Liu,

Hu,

Lin

et al. 2024

Flex. Print. Electron.

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Direct ink writing (DIW) represents a technical branch of additive manufacturing technology, particularly suitable for prototyping or small-batch printing production of printed electronic components. However, the existing print heads required for near or sub-100 μm line width are quite sophisticated, limiting the accessibility and application of the DIW method. This paper reports the use of the vibrating membrane ejector (VME) as a new option for the print head of DIW. The structure of the VME-based print head was specially designed for this purpose. Finite element modeling of the VME’s vibration characteristics was performed to provide insights into the ejection condition and behaviors. The factors influencing the size of printed structures were identified and analyzed through the printing of a metal-organic complex silver (Ag) ink. After optimizing several operational parameters to limit the spreading effects and suppress the satellite droplets, the DIW printed line width has reached about 100 μm. The effectiveness of the VME-based print head was further demonstrated through the DIW fabrication of interdigitated electrodes (IDEs) and microstrip transmission lines. This highlights the versatility of the VME-based print head as a practical tool for device prototyping and ink development in the field of printed electronics.

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“…Simulation studies of the nebulizer structure can help optimize the design, gain a deeper understanding of the mechanism, and optimize parameters. Fossat et al [28] investigated the mechanical behavior of an ultrasonic mesh atomizer using four analytical models. The models considered modal analysis, kinematics of perforations, and the effects of a stepped plate and piezoelectric ring, and the models' validity was confirmed through finite-element frequency domain computations.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Vibrating Mesh Nebulizer Air Inlet Structure for Pulmonary Drug Delivery

Liu,

Chen,

et al. 2023

Atmosphere

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The vibrating mesh nebulizer (VMN) has gained popularity for its compactness and noiselessness. This study investigates the impact of different air inlet structures on the deposition fraction (DF) of droplets generated by VMNs in an idealized mouth–throat (MT) airway model. Three homemade VMNs with semi-circular inlet, symmetrical four-inlet, and multiple-orifice inlet structures were evaluated through simulations and experiments. The changes in droplet DF of 0.9% w/v concentration of nebulized sodium chloride (NaCl) droplets as a function of inertial parameters were acquired under different inhalation flow conditions. Additionally, flow field distributions in models with different inlet structures were analyzed at a steady inspiratory flow rate of 15 L/min. The results indicate that optimizing the VMN’s air inlet structure significantly enhances droplet delivery efficiency. The multiple–orifice inlet structure outperformed the other designs, directing the airflow from the inlet position to the center of the mouthpiece and then into the oral cavity, achieving a DF of up to 20% at an inhalation flow rate of 15 L/min. The region of high airflow velocity between the mouthpiece and oral cavity proved to be a favorable VMN inlet optimization, reducing direct droplet–wall collisions and improving delivery efficiency. These findings offer insights for VMN design and optimization to enhance pulmonary drug delivery effectiveness and therapeutic outcomes.

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Analytical model of the dynamic behavior of a vibrating mesh nebulizer for optimal atomization efficiency

Cited by 7 publications

References 16 publications

Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives

Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives

A vibrating membrane ejector for direct ink writing of printed electronics

Optimization of Vibrating Mesh Nebulizer Air Inlet Structure for Pulmonary Drug Delivery

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