In order to solve the uniqueness of the compliance equations and each notch profile, a curvature-adjustable multiple-axis flexure hinge with complex notch profiles is designed and investigated based on Bézier curve in this paper. The hinge can evolve into multiple-axis flexure hinges with single and hybrid, symmetric and asymmetric notch profiles composed of the ellipse, circle, hyperbola and parabola. In addition, analytical compliance equations in six degrees of freedom based on the Castigliano’s Second Theorem are proposed. Then, a simplified notch profile classification method based on a binary quadratic implicit equation is proposed. Moreover, analytical compliance equations are validated by finite element analysis. The maximum relative error between the finite element analysis and the analytical results is 6.07%. Finally, the compliance, precision of rotation and stress are investigated based on structural parameters. The results show that the change in the rotation centre does not significantly affect the axial and bending compliance for the flexure hinge with a specific single and flush Bézier curve notch profile. Moreover, the flexure hinge with a notch profile consisting of ellipse and hyperbola has the highest rotational precision. The proposed curvature-adjustable multiple-axis flexure hinge can provide more compliance options for the design of compliant mechanisms.