Analytical particle measurements in an optical microflume

Taylor, Joseph D.; Terray, Alex; Hart, Sandra G.

doi:10.1016/j.aca.2010.04.062

Cited by 10 publications

(20 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The efficiency of particle fractionation can be further increased by cascading several optical chromatography regions with different parameters of the incident beam [15]. Using the above experimental procedure, optical chromatography has been successfully applied for discerning micron-sized polystyrene beads differing as little as 70 nm in diameter [404], for quantifying the optical forces acting on hybrid dielectric-metal core-shell particles [405], for the real-time monitoring of immunological reactions between antibody-coated beads and antigen suspended in the host medium [406,407], and for the fractionation of blood cells [408]. We refer the reader to review [21] for additional examples of applications of optical chromatography.…”

Section: Optical Chromatographymentioning

confidence: 99%

Perspective on light-induced transport of particles: from optical forces to phoretic motion

et al. 2019

View full text Add to dashboard Cite

Propulsive effects of light, which often remain unnoticed in our daily-life experience, manifest themselves on spatial scales ranging from subatomic to astronomical. Light-mediated forces can indeed confine individual atoms, cooling their effective temperature very close to absolute zero, as well as contribute to cosmological phenomena such as the formation of stellar planetary systems. In this review, we focus on the transport processes that light can initiate on small spatial scales. In particular, we discuss in depth various light-induced mechanisms for the controlled transport of microscopic particles; these mechanisms rely on the direct transfer of momentum between the particles and the incident light waves, on the combination of optical forces with external forces of other nature, and on light-triggered phoretic motion. After a concise theoretical overview of the physical origins of optical forces, we describe how these forces can be harnessed to guide particles either in continuous bulk media or in the proximity of a constraining interface under various configurations of the illuminating light beams (radiative, evanescent, or plasmonics fields). Subsequently, we introduce particle transport techniques that complement optical forces with counteracting forces of non-optical nature. We finally discuss particle actuation schemes where light acts as a fine knob to trigger and/or modulate phoretic motion in spatial gradients of non-optical (e.g., electric, chemical, or temperature) fields. We conclude by outlining possible future fundamental and applied directions for research in light-induced particle transport. We believe that this comprehensive review can inspire diverse, interdisciplinary scientific communities to devise novel, unorthodox ways of assembling and manipulating materials with light.

show abstract

Section: Optical Chromatographymentioning

confidence: 99%

Perspective on light-induced transport of particles: from optical forces to phoretic motion

et al. 2019

View full text Add to dashboard Cite

show abstract

“…By controlling the pressure above the liquid in each vessel, pulse-free, stable, and reproducible fluid flow could be achieved. 57 In this system, a custom printed circuit board (PCB) was fabricated to both supply 24 V power and convey the control signal from a computer through the use of a 16-bit, 8 channel, high-drive, data acquisition, analog output device (Measurement Computing, Norton, MA, USA) to each of the 5 electronic pressure controllers (EPCs) from Parker-Hannifin (Cleveland, OH, USA). The multi-reservoir technique isolated the flow system, increasing the stability and adding the capability to control the direction of flow.…”

Section: B Fluidic System and Connectionsmentioning

confidence: 99%

Dynamic radial positioning of a hydrodynamically focused particle stream enabled by a three-dimensional microfluidic nozzle

et al. 2015

View full text Add to dashboard Cite

The ability to confine flows and focus particle streams has become an integral component of the design of microfluidic systems for the analysis of a wide range of samples. Presented here is the implementation of a 3D microfluidic nozzle capable of both focusing particles as well as dynamically positioning those particles in selected flow lamina within the downstream analysis channel. Through the independent adjustment of the three sheath inlet flows, the nozzle controlled the size of a focused stream for 6, 10, and 15 μm polystyrene microparticles. Additional flow adjustment allowed the nozzle to dynamically position the focused particle stream to a specific area within the downstream channel. This unique ability provides additional capability and sample flexibility to the system. In order to gain insight into the fluidic behavior of the system, experimental conditions and results were duplicated within 4.75 μm using a COMSOL Multiphysics(®) model to elucidate the structure, direction, proportion, and fate of fluid lamina throughout the nozzle region. The COMSOL Multiphysics model showed that the position and distribution of particles upon entering the nozzle have negligible influence over its focusing ability, extending the experimental results into a wider range of particle sizes and system flow rates. These results are promising for the application of this design to allow for a relatively simple, fast, fully fluidically controlled nozzle for selective particle focusing and positioning for further particle analysis and sorting.

show abstract

“…Later, researchers employed this technique for size-based fractionation and sorting of organic particles including human blood constituents including erythrocytes, monocytes, granulocytes, and lymphocytes [2,5]. Subsequently, differentiation of micronscale bioparticles with subtle differences [4,7], including those with size differences as small as 70 nm [8], are shown. In addition to size-based separation, OC technique also offers refractive index-based fractionation capability, allowing separation of bioparticles with minuscule differences in chemical composition, such as Bacillus anthracis and Bacillus thuringiensis [4] and cells with single gene modifications [3].…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Nanopores: Optofluidic Separation of Nano-Bioparticles via Negative Depletion

Zhu¹,

Çiçek²,

Li³

et al. 2021

Nanopores

View full text Add to dashboard Cite

In this chapter, we review a novel “optofluidic” nanopore device enabling label-free sorting of nano-bioparticles [e.g., exosomes, viruses] based-on size or chemical composition. By employing a broadband objective-free light focusing mechanism through extraordinary light transmission effect, our plasmonic nanopore device eliminates sophisticated instrumentation requirements for precise alignment of optical scattering and fluidic drag forces, a fundamental shortcoming of the conventional optical chromatography techniques. Using concurrent optical gradient and radial fluidic drag forces, it achieves self-collimation of nano-bioparticles with inherently minimized spatial dispersion against the fluidic flow. This scheme enables size-based fractionation through negative depletion and refractive-index based separation of nano-bioparticles from similar size particles that have different chemical composition. Most remarkably, its small (4 μm × 4 μm) footprint facilitates on-chip, multiplexed, high-throughput nano-bioparticle sorting using low-cost incoherent light sources.

show abstract

Analytical particle measurements in an optical microflume

Cited by 10 publications

References 28 publications

Perspective on light-induced transport of particles: from optical forces to phoretic motion

Perspective on light-induced transport of particles: from optical forces to phoretic motion

Dynamic radial positioning of a hydrodynamically focused particle stream enabled by a three-dimensional microfluidic nozzle

Plasmonic Nanopores: Optofluidic Separation of Nano-Bioparticles via Negative Depletion

Contact Info

Product

Resources

About