Analytical performance of free and total thyroxine assays

Nelson, Jerald C.; Wilcox, R. Bruce

doi:10.1093/clinchem/42.1.146

Cited by 74 publications

(20 citation statements)

References 34 publications

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“…The diagnosis is further complicated by the fact that a serum free T4 concentration within the population reference range, similar to the situation of primary hypothyroidism, does not exclude CH 32 and the performance of free T4 assays varies considerably particularly at the lower end of the reference range. 40 Although T3 is the biologically active thyroid hormone, the serum concentration of T3 is not a reliable marker of hypothyroidism and its measurement is not recommended for the diagnosis of hypothyroidism. 41,42 A recent study has suggested that the use of the TSH index (a mathematical model that incorporates both free T4 and TSH values) is more sensitive in diagnosing TSH deficiency than free T4 and TSH measurements alone.…”

Section: The Hypothalamic-pituitary-thyroid Axismentioning

confidence: 99%

The interaction between growth hormone and the thyroid axis in hypopituitary patients

Behan

Monson

Agha

2011

Clinical Endocrinology

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SummaryAlterations in the hypothalamo-pituitary-thyroid axis have been reported following growth hormone (GH) administration in both adults and children with and without growth hormone deficiency. Reductions in serum free thyroxine (T4), increased tri-iodothyronine (T3) with or without a reduction in serum thyroid-stimulating hormone secretion have been reported following GH replacement, but there are wide inconsistencies in the literature about these perturbations. The clinical significance of these changes in thyroid function remains uncertain. Some authors report the changes are transient and revert to normal after a few months or longer. However, in adult hypopituitary patients, GH replacement has been reported to unmask central hypothyroidism biochemically in 36-47% of apparently euthyroid patients, necessitating thyroxine replacement and resulting in an attenuation of the benefit of GH replacement on quality of life in those who became biochemically hypothyroid after GH replacement. The group at highest risk are those with organic pituitary disease or multiple pituitary hormone deficiencies. It is therefore prudent to monitor thyroid function in hypopituitary patients starting GH therapy to identify those who will develop clinical and biochemical features of central hypothyroidism, thus facilitating optimal and timely replacement.

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Section: The Hypothalamic-pituitary-thyroid Axismentioning

confidence: 99%

The interaction between growth hormone and the thyroid axis in hypopituitary patients

Behan

Monson

Agha

2011

Clinical Endocrinology

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“…Although total serum T4 and T3 concentrations were high-normal, the high free T4 (unbound portion) and the low TSH concentration coupled with the clinical signs were diagnostic for hyperthyroidism (Lerro andothers 1985, O'Malley andothers 1989). Serum free T4 concentration by dialysis has been found to be a more sensitive test than total T4 concentration for diagnosis of hyperthyroidism in human and cats (Peterson andothers 1995, Nelson andWilcox 1996). Low serum TSH is expected, because the high circulating, free thyroid hormone concentration feeds back on the pituitary thyrotrope to suppress TSH secretion (Lerro andothers 1985, O'Malley andothers 1989).…”

Section: Discussionmentioning

confidence: 99%

Horner's syndrome associated with a functional thyroid carcinoma in a dog

Melián

Morales

Monteros

et al. 1996

J of Small Animal Practice

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A seven-year-old entire male Irish setter was presented because of a neck mass, prolapse of the third eyelid and apparent drooping of the upper eyelid. Historical findings included increased appetite as well as polyuria and polydipsia for about two weeks. The most remarkable findings on physical examination were right-sided Horner's syndrome, pre-scapular lymphadenopathy and a large, ventral cervical mass. Lateral cervical radiographs showed a large, soft tissue opacity surrounding the trachea and retropharyngeal area which was causing displacement and narrowing of the cervical trachea and oesophagus. Results of thyroid testing suggested hyperthyroidism. At necropsy, a large, invasive tumour was identified in the ventral cervical region and multiple metastases of various sizes were detected in the lungs. Histopathological examination of the tumour revealed follicular thyroid carcinoma and confirmed widespread pulmonary metastasis.

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“…10 TSH was analyzed by immunoenzymometric assay method using ERBA THYROKIT. 11 The level of cholesterol was determined by CHOD-PAP method. 12 Triglycerides were analyzed by GPO/POD method.…”

Section: Methodsmentioning

confidence: 99%

Effect of high blood pressure on thyroid and lipid profile of pregnant women

Gill¹,

Kaur²,

Singh³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertension is common medical problem encountered during pregnancy, complicating up to 10% pregnancies. Hypertension is defined as the systolic blood pressure ≤140 mmHg and a diastolic blood pressure ≥90 mmHg on two separate measurements at least 4-6 hours apart. During pregnancy thyroid demand changes with increased iodine uptake and synthesis of thyroid hormone. Serum from pre-eclamptic women had both a higher ratio of free fatty acid to albumin and increase up take of free fatty acids, which are further esterified to triglyceride. The aim of the present study was to evaluate thyroid hormone, lipid profile and urine albumin in hypertensive pregnant women and its comparison with normotensive pregnant womenMethods: Total 90 samples were collected from Beri Maternity Hospital and Civil Hospital, Amritsar. Blood samples were analysed for biochemical parameters viz. lipid profile and thyroid profile. Urine samples were also analysed for presence of albumin.Results: From the study it has been revealed that thyroid stimulating hormone (TSH) levels increased in hypertensive pregnant women mean (4.26±1.1µ/ml). The total cholesterol (234.56±14.2mg/dl), triglyceride (138±16.96mg/dl), HDL (50.7±7.4mg/dl), LDL (156.2±17.11mg/dl) and VLDL (27.7±3mg/dl) was found altered in hypertensive pregnancy as compared to normotensive pregnancy. The albumin excretion was seen in 13.3% hypertensive pregnancies.Conclusions: TSH were elevated in hypertensive pregnant women due to the effects of estrogen. Among all the parameters of lipid profile, total cholesterol, TG, LDL and VLDL has been increased significantly in hypertensive pregnant women as compared to normotensive pregnant women due endothelial dysfunction.

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Analytical performance of free and total thyroxine assays

Cited by 74 publications

References 34 publications

The interaction between growth hormone and the thyroid axis in hypopituitary patients

The interaction between growth hormone and the thyroid axis in hypopituitary patients

Horner's syndrome associated with a functional thyroid carcinoma in a dog

Effect of high blood pressure on thyroid and lipid profile of pregnant women

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