Analytical Procedure for Determination of Cyclooxygenase-2 Inhibitors in Biological Fluids by High Performance Liquid Chromatography: A Review

Carlucci, Giuseppe

doi:10.2174/187152309787580829

Cited by 3 publications

(1 citation statement)

References 126 publications

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“…Non‐steroidal anti‐inflammatory drugs (NSAIDs) can cause adverse drug reactions due to their frequent usage and interaction with a wide range of other medications . Thus, development of efficient and reliable assays to monitor levels of NSAIDs in biological fluids has been extensively studied . Zaltoprofen (ZPF) is an NSAID from the propionic acid family and selectively inhibits the activity of cyclooxygenase‐2, as well as the production of prostaglandin E2 at sites of inflammation .…”

Section: Introductionmentioning

confidence: 99%

Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection

Han

Jeong

Yoo

et al. 2017

J of Separation Science

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A readily applicable method was developed to determine the concentration level of zaltoprofen, a non-steroidal antiinflammatory drug from the propionic acid family, in human plasma. This method is based on manual-shaking-assisted dispersive liquid-liquid microextraction coupled with liquid chromatography with ultraviolet detection. Factors affecting the extraction efficiency were screened and optimized by experimental design using fractional factorial and central composite designs, respectively. Optimal conditions were: 220 μL of C H Cl (extraction solvent), 5 mL of 3.75% w/v NaCl aqueous solution at pH 2.0, and manual shaking for 13 s (65 times). The resulting extraction method yielded a reasonable enrichment factor of 18.0 (±0.6, n = 3) and extraction recovery of 86.0% (±3.3%, n = 3). The established method was validated for selectivity, linearity, precision, accuracy, matrix effect, recovery, dilution integrity, and stability, and it met the acceptable criteria for all of the tested parameters. Specifically, the method was linear in the range of 0.16-50.0 mg/L, precise (< 8.8% RSD), accurate (-7.5-5.6% deviation), and showed negligible matrix effects (96.1-106.4%) with high absolute recovery (94.5-97.7%). Compared with previous methods involving labor-intensive liquid-liquid extraction or non-specific protein precipitation, our method allows the simple, rapid, and efficient determination of zaltoprofen using the most affordable analytical instrument, liquid chromatography with ultraviolet detection.

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Section: Introductionmentioning

confidence: 99%

Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection

Han

Jeong

Yoo

et al. 2017

J of Separation Science

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Polyaniline-deposited cellulose fiber composite prepared via in situ polymerization: enhancing adsorption properties for removal of meloxicam from aqueous media

et al. 2017

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Chromatographic techniques in analysis of cyclooxygenase-2 inhibitors in drugs and biological samples

Starek

Dąbrowska

2012

Open Chemistry

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Non-steroidal anti-inflammatory drugs, as a therapeutic class, are among the most often used active pharmaceutical ingredients in heath care in the world. They are mostly available without prescription and often used for treatment of fever and pain. An extensive research of the literature published in analytical and pharmaceutical chemistry journals has been conducted and the chromatographic methods which were used for the purity, stability and pharmacokinetic studies of the cyclooxygenase-2 inhibitors, in formulations and biological materials have been reviewed. The methodology for the analysis of selected drugs is very well documented and many examples are available in the literature. The common use of chromatographic techniques with various detection attachments provide possibility for monitoring of drugs in therapy.

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Analytical Procedure for Determination of Cyclooxygenase-2 Inhibitors in Biological Fluids by High Performance Liquid Chromatography: A Review

Cited by 3 publications

References 126 publications

Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection

Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection

Polyaniline-deposited cellulose fiber composite prepared via in situ polymerization: enhancing adsorption properties for removal of meloxicam from aqueous media

Chromatographic techniques in analysis of cyclooxygenase-2 inhibitors in drugs and biological samples

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