Analytical procedure for the determination of tetracyclines in medicated feedingstuffs by liquid chromatography-mass spectrometry

Patyra, Ewelina; Kwiatek, K.

doi:10.1515/jvetres-2016-0006

Cited by 21 publications

(5 citation statements)

References 23 publications

(19 reference statements)

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“…These include HPLC with UV detection [33][34][35][36][37][38][39][40], HPLC with fluorescence detection [41,42] liquid chromatography with mass spectrometry [43,44]. Nowadays, liquid chromatography coupled with mass spectrometry and tandem mass spectrometry seem to be the techniques of choice for analysis of these groups of antibiotics [45].…”

Section: Methods For the Determination Of Tcs Residues In Honeymentioning

confidence: 99%

Tetracyclines Residues in Honey

Buzia¹,

Ploscutanu²,

Elisei³

2019

Rev. Chim.

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Antibiotic residues have toxic acute and chronic effects on human health and also reduce the efficacy and quality of honey. This review was conducted aiming to evaluate the tetracyclines (TCs) residues in honey, compared to international standards available in this field. In conclusion, our study demonstrated that a worldwide concerted effort is required to uphold the all-natural, wholesome and clean and green image of honey.

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Section: Methods For the Determination Of Tcs Residues In Honeymentioning

confidence: 99%

Tetracyclines Residues in Honey

Buzia¹,

Ploscutanu²,

Elisei³

2019

Rev. Chim.

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“…The injection volume was 3 µl and all compounds were eluted within 15 min. The LC-MS parameters were published by Patyra and Kwiatek in 2016 [8].…”

Section: Lc-ms Was Carried Out Using An Lc-ms System Formmentioning

confidence: 99%

“…For the extraction of tetracyclines from biological matrices the most common using solvent is McIlvaine buffer with EDTA pH 4 [2,8,[12][13][14]. Many researchers also used a solution of succinic [1,4], hydrochloric, perchloric, phosphoric, oxalic acid or imidazolic buffer for extraction tetracyclines [7,26,[28][29][30][31][32], as well as mixtures such as: ethyl acetate and citric buffer [28] but also citric buffer and acetonitrile [7,15].…”

Section: Sample Preparationmentioning

confidence: 99%

“…Moreover, tetracyclines are subject to chelation with the transition metal ions, such as Fe 2+ , Fe 3+ , Al 3+ , Cr 3+ , Mn 2+ , Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ , Cd 2+ , Hg 2+ , and salts with alkali and alkaline earth metals and organic and inorganic acids (e.g., citric, boric, and humic acids) [7]. Therefore, for the extraction of tetracycline-class antibiotics the McIlvaine buffer containing EDTA is the most widely used solution, due to its properties of complexing metal cations [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of HPLC–DAD and LC–MS Techniques for the Determination of Tetracyclines in Medicated Feeds Using One Extraction Protocol

Patyra

Kwiatek

2021

Chromatographia

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Four antibiotics, oxytetracycline, tetracycline, doxycycline, and chlortetracycline were separated and quantified in medicated feed. Tetracyclines from feed samples were extracted with 0.01 M citric buffer and acetonitrile (pH 3.0) and further purified with 0.45 µm syringe filters. The purified extract was separated on commercial RP-C18 column and analyzing using liquid chromatograph (LC) with two different detectors: diode array detector (DAD) and mass spectrometry (MS). These methods provided average recoveries from 72.2 to 101.8% for high pressure liquid chromatography (HPLC) with diode array detection and from 45.6 to 87.0% for liquid chromatography with mass spectrometry. The limit of detection in medicated feed ranged from 4.2 to 10.7 mg kg−1 for HPLC–DAD and 5.6 to 10.8 mg kg−1 for LC–MS. Our experiment showed that using the same extraction mixture we do not obtain the same recovery values for the analyzed compounds using two different detection techniques such as DAD and MS.

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“…[ 4,5 ] Therefore, establishment of a simple, fast, and sensitive method for antibiotic analysis is highly valued by researchers. [ 6 ] Traditional tetracycline detection methods include mainly microbial methods, [ 7 ] enzyme‐linked immunoassay [ s, 8 ] liquid chromatography‐mass spectrometry (LC–MS) [ 9 ] and fluorescence spectroscopy. [ 10 ] However, most of these methods require expensive instruments and inconvenient and time‐consuming sample pretreatment, and their comparatively low sensitivity and selectivity still cannot be ignored.…”

Section: Introductionmentioning

confidence: 99%

Ratiometric fluorescent probe for tetracycline detection based on waste printing paper

Liu

Wang

et al. 2021

Luminescence

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Tetracycline (TC) is a broad‐spectrum antibiotic used to treat bacterial infections. In this study, a ratiometric fluorescence (FL) probe was developed to detect TC in water samples using waste printing paper extract as a FL indicator. For this ratiometric probe, the emission of printing paper extract at 436 nm gradually decreased and the emission of a mixed solution at 538 nm significantly increased with the sequential addition of TC upon excitation at 390 nm, coupled with a marked FL colour change from bright blue to faint yellow. Therefore, a ratiometric F538/F436 FL probe was created for TC detection by simply mixing the printing paper extraction and TC. Under the optimized conditions, a linear range from 1 to 100 μM and a detection limit of 0.48 μM (S/N = 3) for TC were obtained. Importantly, the FL probe can be easily prepared with rapid response, high sensitivity, and good selectivity. The application of waste printing paper extract for detection of TC in environmental water samples was demonstrated.

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Analytical procedure for the determination of tetracyclines in medicated feedingstuffs by liquid chromatography-mass spectrometry

Cited by 21 publications

References 23 publications

Tetracyclines Residues in Honey

Tetracyclines Residues in Honey

Comparison of HPLC–DAD and LC–MS Techniques for the Determination of Tetracyclines in Medicated Feeds Using One Extraction Protocol

Ratiometric fluorescent probe for tetracycline detection based on waste printing paper

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