Analytical procedures for the detection and characterization of apolipoprotein E mutants

Assmann, Gerd; Funke, Harald; Jabs, H.-U.

doi:10.1016/0002-8703(87)90639-9

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…The ∊3 allele, considered to be the parental allele, has cystine at codon 112 and arginine at codon 158. 19 The ∊2 allele has cystine at both positions, while the ∊4 allele contains arginine at both positions. 19 The APOE ∊3 allele and homozygous ∊3∊3 genotype were most prevalent in controls, whereas APOE ∊4 allele and heterozygous ∊3∊4 genotype in AD.…”

Section: Discussionmentioning

confidence: 99%

Gene–Environment Interaction in Alzheimer’s Disease

Singh

Chhillar

Banerjee

et al. 2012

Am J Alzheimers Dis Other Demen

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Section: Discussionmentioning

confidence: 99%

Gene–Environment Interaction in Alzheimer’s Disease

Singh

Chhillar

Banerjee

et al. 2012

Am J Alzheimers Dis Other Demen

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“…The three common isoforms of apolipoprotein E (apo E2, apo E3 and apo E4), specified by a locus on chromosome 19 (Des et al 1985), differ at amino acids 112 and 158 (Table 1) (Assman et al 1987). In most epidemiological studies the ~4 allele is predictive of increased cholesterol and LDLcholesterol (LDL-C) levels and a higher risk of ischaemic heart disease, while the ~2 allele is associated with a reduced risk and with lower cholesterol and LDL-C concentrations (Davignon et al 1988, Utermann 1987.…”

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confidence: 99%

Apolipoprotein E allele frequencies in a South African Indian female population

et al. 1995

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Coronary heart disease is common amongst South Africans of Indian (Asian) ancestry. As part of an investigation into risk factors in premenopausal and post‐menopausal Indian nurses, we determined the apolipoprotein E genotype by means of restriction isotyping on 173 healthy nurses between the ages of 25–55 years. The apolipoprotein E allele frequencies on 346 chromosomes were: ε2, 1.2% (95% confidence interval 0.06‐2.66); ε3, 87.6% (95% confidence interval 84.1–91.1 and ε4, 11.3% (95% confidence interval 7.94‐14.60). No ε2/2 homozygotes were encountered. Our results demonstrate an extremely low frequency of the ε2 allele, a low‐normal apo ε4 and a high ε3 allele frequency. It is unlikely that apolipoprotein E polymorphism contributes to the high incidence of coronary heart disease in this population.

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Laboratory procedures in preventive cardiology

Soufi

Noll

Herzum

et al. 1999

Herz

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In recent years a large number of coronary artery disease risk factors were discovered. The knowledge of these factors improves the estimate of the coronary artery disease (CAD) risk--however it still remains to be only an "estimate". A perfect prediction of an upcoming CAD event is not possible, despite all high score laboratory technology. Therefore the use of specialized laboratory procedures should be applied carefully. Knowing the blood levels of cholesterol, triglycerides, HDL- and LDL-cholesterol and Lp(a) can be sufficient for many therapeutical decisions. Severe dyslipidemia, familial CAD and CAD without any obvious reasons demand a more specialized work-up, however, risk stratification factors such as family history, clinical history (CAD, hypertension, diabetes mellitus, smoker) and genetics are crucial, apart from the above mentioned laboratory values. Purely on the basis of the lipidologic baseline concentrations we can't give well based recommendations for the treatment of individual patients. Currently there are expert systems available which allow a risk estimate once important laboratory values (LDL cholesterol, HDL cholesterol, Triglycerides) as well as clinical data (blood pressure, family history, clinical history) are available. This system can be accessed by internet under "http:/(/)www.chd-taskforce.com".

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Analytical procedures for the detection and characterization of apolipoprotein E mutants

Cited by 5 publications

References 25 publications

Gene–Environment Interaction in Alzheimer’s Disease

Gene–Environment Interaction in Alzheimer’s Disease

Apolipoprotein E allele frequencies in a South African Indian female population

Laboratory procedures in preventive cardiology

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