Analytical profile of Brahmi Ghrita: A polyherbal Ayurvedic formulation

Gubbannavar, Jyoti S; Chandola, HM; Harisha, C R; Kalyani, Renuka; Shukla, Vinay J

doi:10.4103/0974-8520.105254

Cited by 12 publications

(9 citation statements)

References 1 publication

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“…Kalka containing clarified butter made from cow milk (cow ghee or Go Ghrita) is liquefied under moderate flame and the Swarasa is then added to it in prescribed quantities to form Brahmi Ghrita [70,71] . Methanolic extract of EBm and lipid extraction of EBm showed comparable results as Brahmi Ghrita when administered in doses of 200 mg/kg to rats for 2 weeks [72] .…”

Section: Current Practice Of Brahmi In Ad Brahmi Is Administered As Vmentioning

confidence: 99%

Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease

Chaudhari

Tiwari

Tiwari³

et al. 2017

Ann Neurosci

137

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Section: Current Practice Of Brahmi In Ad Brahmi Is Administered As Vmentioning

confidence: 99%

Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease

Chaudhari

Tiwari

Tiwari³

et al. 2017

Ann Neurosci

137

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“…As a vehicle for drugs, ghee has been considered as a promising, due to its ability to easily cross the blood brain barrier. Thus, most of the Ayurvedic formulations acting on psyche recommends its use [33]. More importantly, ghrita (ghee) along with triphala churna have been used for the treatment of eye disorders [34].…”

Section: Discussionmentioning

confidence: 99%

Carbon Based Kajal Formulations: Antimicrobial Activity and Feasibility as a Semisolid Base for Ophthalmics

Randive

Bhinge²,

Jadhav

et al. 2020

JPRI

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Study aimed to prepare and evaluate carbon based kajal formulation and carry out its comparative evaluation with the marketed formulations of kajal. Initially, carbon soot was deposited on Aloe vera mucilage spreaded on a copper plate, in specifically designed apparatus. Subsequently, sun dried plate was allowed to expose to the flame of cow ghee for 1 hr. Soot which was deposited on the copper plate was scrapped and Characterization of Soot by SEM, TEM, FTIR, XRD and EDX was carried out and kajal was prepared by adding few drops of cow ghee to it. The kajal was compared with the five marketed kajal formulations available in India, on the basis of physical characteristics their antibacterial potential was also assessed against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. All the formulations exhibited almost similar physical characteristics. The prepared kajal showed pH (7.06±0.13). The antimicrobial activity of the marketed formulations was comparatively less than that of freshly prepared exhibiting zone of inhibition 13.05±0.11, 20.08± 0.13 and 22.06±0.18 mm against Pseudomonas aeruginosa, Staphylococcus aureus, and E. coli respectively. EDX spectra, revealed that the cow ghee soot have the weight percentage of carbon and copper as 79.20 and 17.10% respectively and Confirmed the absence of Lead (Pb). The eye irritation test (OECD 405) also showed no any irritation, redness, watering of the eye or swelling was not observed for prepared formulation in test animal. Prepared Kajal can be safely used for beatification and also in the treatment of eye diseases especially in pediatrics.

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“…[10] Analytical Study Brahmi ghrita has higher acid, saponification, iodine and refractive index in comparison to Ghrita and phytochemical like bacosides are present in it. [11] Animals Charles Foster rats weighing between 160 and 180 g and Swiss albino mice weighing between 20 and 30 g were used for experimental study. The animals were obtained from the Central Animal House.…”

Section: Preparation Of Brahmi Ghritamentioning

confidence: 99%

Acute and sub-chronic toxicity study of Brahmi ghrita in rodents

Reddy¹,

Kumar²,

Yadav³

2014

Int J Green Pharm

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Context: Brahmi Ghrita (BG) contains Brahmi (Bacopa monneri), Vacha (Acorus calamus), Kushtha (Saussurea lappa), Shankhapushpi (Convolvulus pluricaulis) and Puran Ghrita, mentioned for treatment of various diseases. Aim: To assess acute and sub-chronic toxicity of Brahmi Ghrita in mice and rats, respectively. Materials and Methods: In acute toxicity study, Swiss strain albino mice were administered orally Brahmi Ghrita doses of 1, 2.5 and 5 g/kg and observed for behavioural changes and mortality, if any. In sub chronic toxicity study, Charles Foster albino rats were administered two doses of Brahmi Ghrita i.e., 400 and 800 mg/kg, p.o. for 30 consecutive days. During 30 days of treatment, rats were observed for any changes in body weight and daily food and water intake. After 30 days, rats were sacrificed for haematological, biochemical and histopathology study. Result: There was no mortality or abnormal behaviour, observed in acute toxicity study in mice at all the three dose levels. In sub-chronic toxicity study, Brahmi Ghrita did not produce any significant changes in body weight and daily food and water intake of rats when compared to control group rats. Further, haematological and biochemical parameters were also found normal. Histopathological study revealed normal architecture of kidney and liver of Brahmi ghrita treated rats. Conclusion: Brahmi Ghrita is safe in rodent and mice.

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Analytical profile of Brahmi Ghrita: A polyherbal Ayurvedic formulation

Cited by 12 publications

References 1 publication

Neurocognitive Effect of Nootropic Drug <b><i>Brahmi</i></b> (<b><i>Bacopa monnieri</i></b>) in Alzheimer's Disease

Neurocognitive Effect of Nootropic Drug <b><i>Brahmi</i></b> (<b><i>Bacopa monnieri</i></b>) in Alzheimer's Disease

Carbon Based Kajal Formulations: Antimicrobial Activity and Feasibility as a Semisolid Base for Ophthalmics

Acute and sub-chronic toxicity study of Brahmi ghrita in rodents

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