Considering the serious wear of disk cutters in tunnel project and the low prediction accuracy of existing methods, a new method for wear prediction of disk cutters from an energy perspective was proposed. Based on contact mechanics, the rock breaking process of cutters was analyzed, and the combined action of sliding and rolling friction was considered. Furthermore, the wear prediction model of disk cutters was established, which realized the predicted wear of disk cutters under different geological conditions throughout the construction line. In addition, considering the influence of penetration on the wear prediction model, the predicted wear values under different penetrations were obtained, and their average values were taken as the predicted wear values of disk cutters considering penetration. Finally, the predicted wear values were compared with the actual wear value of disk cutters. The results showed that the average relative error between the predicted wear value of disk cutters considering sliding and rolling friction and the actual wear data was 12.8%. The average relative error between the predicted value of wear considering only sliding friction and the actual value of disk cutters is 18.3%. The average relative error between the predicted value of disk cutter wear considering penetration and the actual wear data was 12.2%, which proved the feasibility and accuracy of the prediction model. Meanwhile, it is more accurate than the model only considering sliding friction. The research results provided a scientific theoretical basis for the design of a tool change scheme in tunnel construction.