Analytical study of effects of intravenous lignocaine on pressor response during laryngoscopy and intubation

A, Kaleem Siddiqui M; Kiran, N

doi:10.7439/ijbr.v6i2.1670

Int Jour of Biomed Res

2015

DOI: 10.7439/ijbr.v6i2.1670

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Analytical study of effects of intravenous lignocaine on pressor response during laryngoscopy and intubation

Kaleem Siddiqui M A¹,

N Kiran²

Abstract: Induction of general anaesthesia and endotracheal intubation for maintenance of airway and prevention of aspiration is carried out frequently by the anaesthesiologist in day to day practice. This study was aimed to study the effects of lignocaine on pressor response during laryngoscopy and intubation. It was carried out in 50 patients of both sexes, between the age group of 20-60 years, belonging to ASA physical status grade I and II. 2% preservative free lignocaine 1.5mgKg-1 diluted to 10ml over a period of o… Show more

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Cited by 2 publications

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Comparison of intravenous fentanyl versus lidocaine for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing elective surgery in Dilla University Referral Hospital, Ethiopia, a randomized controlled trial

Doba

Ferede

Kasa

et al. 2020

International Journal of Surgery: Global Health

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Background: Laryngoscopy and endotracheal intubation is one of the most stressing moments in technique of general anesthesia. It can cause pressure response and sympato adrenal response due to stimulation of epipharynx and laryngopharynx. The main objective of this study is to compare the effect of intravenous lidocaine and fentanyl for attenuation of hemodynamic response during laryngoscopy and intubation in elective patients who undergo general anesthesia with endotracheal intubation. Methods: A randomized controlled trial was conducted in 52 eligible adults allocated in to 2 group; group F (n=26) patients received fentanyl 2 mcg/kg and group L (n=26) patients received lidocaine (2%) 1.5 mg/kg. The hemodynamic variables were recorded at 1st, 3rd, 5th, and 10th minutes after laryngoscopy and intubation. Kolmogorov test were used to test for distributions of data while homogeneity of variance were assessed using Levene test for equality of variance. Between groups comparison of vital sign were made using independent t test symmetric data and Mann-Whitney U test was used for asymmetric data. A post hoc effect size calculated using G-power. Those variables with P-value <0.05 were considered as statistically significant. Result: The mean rise in heart rate from base line was higher in lidocaine group 29.26±15.02 bpm compared with fentanyl group 17.56±10.28 bpm at first minute. The mean rise in systolic blood pressure from base line at first minute is lower in fentanyl group 17.53±13.04 compared with lidocaine group 31.53±17.24. The mean rise in hemodynamic variables (heart rate, systolic blood pressure, means arterial pressure, and diastolic blood pressure) from base line at 3rd, 5th, and 10th were comparable between groups with (P-value >0.05). Conclusion and Recommendation: Fentanyl at 2 µg/kg is superior in attenuation of hemodynamic response to laryngoscopy and intubation at first minute. There is comparable hemodynamic attenuation effect between groups at 3rd, 5th, and 10th minutes after intubation. Based on this we recommended that use of fentanyl 2 µg/kg better blunt hemodynamic response at first minute where both are equal at 3rd, 5th, and 10th minutes.

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Comparison of intravenous fentanyl versus lidocaine for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing elective surgery in Dilla University Referral Hospital, Ethiopia, a randomized controlled trial

Doba

Ferede

Kasa

et al. 2020

International Journal of Surgery: Global Health

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A Comparative Study between Intravenous Fentanyl and Intravenous Lidocaine on Attenuation of Hemodynamic Pressor Responses to Laryngoscopic Intubation: A Prospective Cohort Study, Ethiopia

Samuel¹,

Melekamayhu²,

Woldeyohannes³

et al. 2019

OJAnes

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Introduction: Laryngoscopic intubation is an insertion of endotracheal tube into the trachea for maintenance of airway during general anesthesia. Smooth intubation requires attenuation of pressor responses and maintenance of baseline hemodynamic stability. The primary outcome of this study is to compare intravenous fentanyl and lidocaine as an anesthetics adjuvant on attenuation of hemodynamic pressor responses to Laryngoscopic intubation in elective surgical adult patients. Methods: This prospective cohort study recruits 114 patients who underwent elective surgery under general anesthesia with laryngoscopy and endotracheal tube intubation. The study was conducted from January 1, 2018 to March 30, 2018. Systemic random sampling technique was used to select the study participants. Those patients that received intravenous fentanyl 2 micrograms per kilogram three minutes before intubation as an anesthetics adjuvant are considered as Fentanyl-group (group F). The Lidocaine-group (group L) was those patients who receive 2% intravenous lidocaine 1.5 milligrams per kilogram three minutes before intubation as anesthetics adjuvant. Hemodynamic parameters (heart rate and blood pressure) and other variables were documented starting from 3 minutes before intubation to 5 minutes after intubation. Results: The mean heart rate at first minute after intubation was significantly lower in fentanyl group (98.91 ± 15.6 beats per minute (bpm)) compared to lidocaine (107 ± 15.45 bpm), t (112) = 2.8, p = 0.006. Systolic blood pressure was also significantly lower in

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Analytical study of effects of intravenous lignocaine on pressor response during laryngoscopy and intubation

Cited by 2 publications

References 11 publications

Comparison of intravenous fentanyl versus lidocaine for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing elective surgery in Dilla University Referral Hospital, Ethiopia, a randomized controlled trial

Comparison of intravenous fentanyl versus lidocaine for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing elective surgery in Dilla University Referral Hospital, Ethiopia, a randomized controlled trial

A Comparative Study between Intravenous Fentanyl and Intravenous Lidocaine on Attenuation of Hemodynamic Pressor Responses to Laryngoscopic Intubation: A Prospective Cohort Study, Ethiopia

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