Low power/area cytomorphic chips may be interfaced and ultimately implanted in the human body for cell-sensing and cell-control applications of the future. In such electronic platforms, it is crucial to accurately mimic the biological time-scales and operate in real-time. This paper proposes a methodology where slow nonlinear dynamical systems describing the behavior of naturally encountered biological systems can be efficiently realised in hardware. To this end, as a case study, a low power and efficient digital ASIC capable of emulating slow intracellular calcium dynamics with time-scales reaching to seconds has been fabricated in the commercially available AMS 0.35 µm technology and compared with its analog counterpart. The fabricated chip occupies an area of 1.5 mm 2 (excluding the area of the pads) and consumes 18.93 nW for each calcium unit from a power supply of 3.3 V. The presented cytomimetic topology follows closely the behavior of its biological counterpart, exhibiting similar time-domain calcium ions dynamics. Results show that the implemented design has the potential to speed up large-scale simulations of slow intracellular dynamics by sharing cellular units in real-time.