Analytical Techniques for Discovery of Bioactive Compounds from Marine Fungi

Gomes, Ana R.; Duarte, Armando C.; Rocha-Santos, Teresa

doi:10.1007/978-3-319-19456-1_9-1

Cited by 5 publications

(2 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on a specific retention time or window, natural products can be selectively or broadly collected, lyophilized, and resolubilized in the appropriate solvent and concentration. The detailed technologies and techniques for isolation and purification of natural products from microbes have been extensively reviewed and explained by previous methodology and review publications (Bucar et al, 2013;Joana Gil-Chávez et al, 2013;Gomes et al, 2017;Zhang et al, 2018a;Atanasov et al, 2021).…”

Section: Enrichment Isolation and Purification Of Natural Productsmentioning

confidence: 99%

Bioprospecting Trichoderma: A Systematic Roadmap to Screen Genomes and Natural Products for Biocontrol Applications

Rush

Shrestha

Meena

et al. 2021

Front. Fungal Biol.

View full text Add to dashboard Cite

Natural products derived from microbes are crucial innovations that would help in reaching sustainability development goals worldwide while achieving bioeconomic growth. Trichoderma species are well-studied model fungal organisms used for their biocontrol properties with great potential to alleviate the use of agrochemicals in agriculture. However, identifying and characterizing effective natural products in novel species or strains as biological control products remains a meticulous process with many known challenges to be navigated. Integration of recent advancements in various “omics” technologies, next generation biodesign, machine learning, and artificial intelligence approaches could greatly advance bioprospecting goals. Herein, we propose a roadmap for assessing the potential impact of already known or newly discovered Trichoderma species for biocontrol applications. By screening publicly available Trichoderma genome sequences, we first highlight the prevalence of putative biosynthetic gene clusters and antimicrobial peptides among genomes as an initial step toward predicting which organisms could increase the diversity of natural products. Next, we discuss high-throughput methods for screening organisms to discover and characterize natural products and how these findings impact both fundamental and applied research fields.

show abstract

Section: Enrichment Isolation and Purification Of Natural Productsmentioning

confidence: 99%

Bioprospecting Trichoderma: A Systematic Roadmap to Screen Genomes and Natural Products for Biocontrol Applications

Rush

Shrestha

Meena

et al. 2021

Front. Fungal Biol.

View full text Add to dashboard Cite

show abstract

“…So, this prompted us to study the inhibition of COVID-19 protease by marine fungi and edible mushroom which is widely used for their high nutritional value and may offer fruitful insights to treat this coronavirus. Therefore, in the present work we have chosen a multitude of antiviral compounds from Mushrooms [10][11][12] such as β glucan, Velutin, Heliantriol F, Adenosin, Iso-sinensetin, Dimethylgluanosine, Lentinan and also from marine fungi [13][14][15] such as Hispolon, Balticolid, Fucan, Galactan, Equisetin, Stachyflin and many more compounds. We have taken the main protease (Mpro) and ACE2 receptor binding domain as active target of this novel corona virus protein and screened with different antiviral compounds found in edible mushrooms and marine fungi using molecular docking tools and molecular dynamic simulation.…”

Section: Introductionmentioning

confidence: 99%

Tapping the Unexplored Potential of Marine Fungi and Edible Mushrooms for in Silico Screening of Anti-Viral Bioactive Compounds Against SARS-CoV-2 for Rapid Development of Nutraceuticals

Srivastav¹,

Jaiswal²,

Kumar

2020

Preprint

View full text Add to dashboard Cite

<p>Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) affects human respiratory function that causes COVID-19 disease. COVID-19 has spread rapidly all over the world and became a pandemic within no time. Therefore, it is the need of hour to screen potential lead candidates from natural resources like edible mushrooms and marine fungi. These natural resources are very less explored till now and known to be the source for many medicinal compounds with several health benefits. These medicinal compounds can be easily exploited for the faster development of nutraceuticals for controlling SARS-CoV-2 infections. Our in-silico research suggests that bioactive compounds originating from mushroom and marine fungi shows strong potential to interact with ACE2 receptor or main protease of SARS-CoV-2, showing the inhibition activity towards the enzymatic protease. We performed a series of in silico studies for the validation of our results, which includes Molecular docking, drug likeness property investigation by Swiss ADME tools, MD simulation, and thermodynamically stable free binding energy calculation. Overall, these results suggest that Ganodermadiol and Heliantriol F bioactive compounds originating from edible mushroom has strong potential to be developed as low-cost nutraceutical against SARS-CoV-2 viral infection. The drug candidate isolated from marine fungi and edible mushroom are highly unexplored for the development of potential alternative drug against SARS-CoV-2 virus with minimum side effects. That is why we decided to screen some active metabolites from the marine fungi and mushrooms, which offer some encouraging results. Though our in-silico studies of these compounds are showing a promising result against SARS-CoV-2 main protease and ACE2 receptor binding domain, the effectiveness of these bioactive compounds should be further validated by proper clinical trials.</p>

show abstract