Analytical validation of the Liaison Calcitonin_II-Gen (DiaSorin)

Abstract

Abstract. 1Background. We validated the DiaSorin Liaison Calcitonin_II-Gen, an improved method for 2

Comparison of Three Automated Calcitonin Immunoassays for Evaluating the Equivalence Near the Clinical Decision Point

“…However, because there were some aberrant high concentrations around 10 pg/mL when using the LIAISON analyzer in our study, we attempted to verify whether false-positive results using this analyzer were reported previously. Our results may be more informative when reviewed in combination with those reported in previous studies [5,23]. Bieglmayer et al Currently, there is no consensus on the reference method for calcitonin measurement.…”

“…In normal endocrine processes, calcitonin inhibits calcium reabsorption from the bones, thereby main-임상적 중요 농도에서의 동등성 평가를 위한 세 가지 칼시토닌 자동 면역검사의 비교 cancer [6,[15][16][17][18][19]. Serum calcitonin concentration testing, like most tests conducted in modern clinical laboratories, is becoming increasingly advanced and automated [5,9,[20][21][22].…”

“…Only few studies have evaluated the equivalence of different calcitonin assays [5,23]. In this context, we compared the serum calcitonin levels measured using three different automated immunochemical analyzers, namely the LIAISON (Diasorin, Saluggia, Italy), Atellica IM 1600 (Siemens Healthcare Diagnostics Inc., New York, USA), and Cobas e801 (Roche Diagnostics GmbH, Mannheim, Germany), to evaluate the equivalence of the test results and determine whether the current clinical calcitonin cut-offs apply to the available calcitonin immunoassays used in clinical laboratories.…”

“…The plasma calcitonin concentration is relatively high in infants, and decreases rapidly until adolescence, leveling off during adulthood [3]. On average, its concentration is higher in men than in women [4,5].…”

Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells

“…Briefly, cells were plated in 60 mm tissue culture dishes and treated for 24, 48 and 72 hrs. At the end of each time interval, the conditioned medium was collected and the CT levels were quantified using LIAISON ® Calcitonin_II‐Gen (DiaSorin Inc., Stillwater, MN, USA), an analytical method that employs a chemiluminescent immunoassay . The experiment was performed in triplicate.…”