Analytische Daten von Brotizolam (Lendormin) und seinen Hauptmetaboliten

Schütz, H.; Schneider, W.-R.

doi:10.1007/978-3-642-71456-6_78

Cited by 1 publication

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“…This well known and documented screening procedure via acid hydrolysis, photolytical dealkylation, diazotization and coupling with Bratton-Marshall reagent to yield azo dyes [17] is applicable to the new benzodiazepines haloxazolam (via ABFB), ethyl 9For publications dealing with the analytical data of a single benzodiazepine see: alprazolam [67], brotizolam [66], clotiazepam [60], halazepam [61], loprazolam [64], midazolam [53], pinazepam [63], tetrazepam [58], triazolam [59] loflazepate and quazepam metabolites (via ACFB), cloxazolam, mexazolam and delorazepam (via ADB), quazepam und metabolites (via CFTB), pinazepam (via CPB), fludiazepam (via CFMB) and nimetazepam (via MNB). Because of its higher specificity and sensitivity, Bratton-Marshall detection should be preferred as a screening method when these benzodiazepines are encountered.…”

Section: Thin-layer Chromatography (Bratton-marshall Detection)mentioning

confidence: 99%

Modern screening strategies in analytical toxicology with special regard to new benzodiazepines

Schütz

1988

Z Rechtsmed

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Screening procedures for the detection of toxicologically relevant substances have become of ever-increasing importance due to the rapid development of new substances. Identification methods must be simple, sensitive, and practicable. This article describes standardized chromatographical (corrected Rcf values, retention indices) and immunological methods (enzyme-multiplied immunoassay technique, fluorescent polarization immunoassay) with special regard to the screening of some newer benzodiazepines, a class of substances that is still expanding. Some of these new compounds may be integrated in well-known screening procedures (via aminobenzophenones and detection by the Bratton-Marshall reagent); others require special concepts for detection. The problems are indicated and discussed, including the use of high-pressure-liquid chromatography and mass spectrometry; recommendations are given.

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Section: Thin-layer Chromatography (Bratton-marshall Detection)mentioning

confidence: 99%

Modern screening strategies in analytical toxicology with special regard to new benzodiazepines

Schütz

1988

Z Rechtsmed

View full text Add to dashboard Cite

show abstract

Analytische Daten von Brotizolam (Lendormin) und seinen Hauptmetaboliten

Cited by 1 publication

References 10 publications

Modern screening strategies in analytical toxicology with special regard to new benzodiazepines

Modern screening strategies in analytical toxicology with special regard to new benzodiazepines

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