Quality of life is one of the most important areas of human well-being explored worldwide. The issue of quality of life, namely its quantification, is a current topic evidenced by a number of literary sources in the literature. We solved this issue in the conditions of the Slovak Republic and within this problem, we analyzed the development of the quality of life parameters for each self-governing region of Slovakia. We calculated a Quality of Life Index for the regions of Slovakia using selected indicators. We compared the quality of life in the regions of Slovakia and selected parameters suitable for calculating the overall index together with the methodology of the index's creation. We found that there are statistically significant differences between regions, in terms of economic, social and environmental factors. The assessment of the quality of life in the regions of Slovakia, as well as the assessment of the quality of life also on the level of Slovakia, even internationally, is an important aspect affecting the further development of society and the existence of humanity itself. so it is essential to find new ways of measuring and assessing negative impacts on the life quality of the population.According to scientists, there is no consensus on the various econometric models that would explain precisely the behavior of individual countries. However, this also causes one to acknowledge that different countries treat their environment differently; that is, they have their specific methods, which can sometimes lead to an improvement in the quality of life of the population in a given country. It is necessary to look for such ways and take comprehensive measures regarding environmental behavior. The attitude of the population towards natural resources is, in most cases, positive because they perceive it as an economic benefit [4,5]. Many studies have found differences in the attitudes between country and city life perceptions [6,7].In most cases, studies focus on gross domestic product. In economic science, the perception throughout society is that the size of the gross domestic product does not automatically reflect people's daily lives, and that there is no linear relationship between the growth of gross domestic product and the improvements in living standards and a better life for the people of the country. This problem is particularly highlighted in the Stiglitz report [8]. However, there are studies that have developed a model based on the population density aspect [9].The influence of the Human Development Index [10-12] was examined in the authors' works. The social impact of politics was examined [13], and it was even stated that better information literacy skills are linked to quality of life [14]. Food satisfaction and various other factors were included in the Social Progress Index. The aspect of tourism was mentioned in works [15,16], and in [17] of the consumption of goods and its impact on the quality of life of the population. Some studies [18] emphasized that this issue must be taken in cooper...