After 30 years since the beginning of the Global Positioning System (GPS), or, more generally, Global Navigation Satellite System (GNSS) meteorology, this technique has proven to be a reliable method for retrieving atmospheric water vapor; it is low-cost, weather independent, with high temporal resolution and is highly accurate and precise. GNSS ground-based networks are becoming denser, and the first stations installed have now quite long time-series that allow the study of the temporal features of water vapor and its relevant role inside the climate system. In this review, the different GNSS methodologies to retrieve atmospheric water vapor content re-examined, such as tomography, conversion of GNSS tropospheric delay to water vapor estimates, analyses of errors, and combinations of GNSS with other sources to enhance water vapor information. Moreover, the use of these data in different kinds of studies is discussed. For instance, the GNSS technique is commonly used as a reference tool for validating other water vapor products (e.g., radiosounding, radiometers onboard satellite platforms or ground-based instruments). Additionally, GNSS retrievals are largely used in order to determine the high spatio-temporal variability and long-term trends of atmospheric water vapor or in models with the goal of determining its notable influence on the climate system (e.g., assimilation in numerical prediction, as input to radiative transfer models, study of circulation patterns, etc.).