Doctors in developing countries lack easy access to independent medication information. 1 The pharmaceutical industry, through its various promotional activities, represents their main source of medication information. 2 The medication package insert (PI) and the medical representatives represent an easily accessible and useful source of medication information for both patients and doctors. 3 The Sudanese regulatory authorities themselves stipulated that the PIs be written for the prescriber and patient, thus primarily targeting doctors with PIs. 4 Patients receive information about their medications, both prescription and over-the-counter, from their health care providers, in verbal form and from the PIs as a written form. The verbal medication information that patients receive from their health care providers, is incomprehensive, deficient, tends to be easily forgotten, misunderstood or not understood. 5-8 Accordingly, patients have to be provided with written medication information. The PIs represent an accessible and an important source of written medication information, which they can read at their convenience and keep for ongoing reference, thus complementing and reinforcing the verbal one, but not replacing it. 9,10 The main objective for this study was to assess the knowledge, attitude, and practice (KAP) of Sudanese doctors towards medication PIs, as easily accessible, available written medication source ABSTRACT Background: Written medication information is important for both doctors and patients. In the developing countries, the medication package inserts (PIs) represent the most available and easily accessible source of written medication information. The main objective of the present study was to assess the knowledge, attitude, and practice of Sudanese doctors toward written medication information in the PIs, and its usefulness for both doctors and patients. Methods: Four hundred (n=400) doctors were randomly selected and addressed with an open to answer the questionnaire composed of fifteen questions (n=15). Results: A big majority (95.7%) of the respondents considered the medications' PIs, which they regularly read (93.2%), as a reliable and useful source of medication information in their prescribing. Only a minority of the respondent doctors (43.6%) used to advise their patients to read the PIs, whereas a majority (62.4%) of respondents believed that patients might find difficulty in understanding written medication information in the PI. The majority (61.3%) of respondent used to rely on pharmacists to provide patients with the needed medication information. The majority of the respondents (82.2%) used to inform their patients about the possible medication side effects. Respondents ranked medications' dose (79.5%), how to use it (77.3%) and information about side effects (73%) on top of patients' medication information most needed particulars. Conclusion: Doctors should give more attention to their patients' medication information specific needs, advice and motivate them to read the PIs before u...