This study was undertaken to analyses the impacts of multiple socioeconomic and biophysical factors influencing food crop production in Mbiame, North West Region of Cameroon. To show this, we used a comprehensive data of socioeconomic and biophysical environment to investigate their potential determinants of food crop output. An assessment on the trend in yields showed a general decreased with soya beans (14.29 percent), maize (18.57 percent), groundnut (18.57 percent), beans (17.14 percent), cocoyam (8.57 percent), Irish potato (14.29) and cassava (8.57). A cause evaluation analysis was undertaken through a farmer participatory approach (with 150 questionnaires) and focus group discussion (Njanawa women's group, mbohnso maize producers, Rifem common initiative group, Mbohchari farmers group and Ngorin farmers group); with a 69.3 percent acceptance that socioeconomic and biophysical factors are responsible for food crop fluctuation.