The potential of Industry 4.0 enabling tools is emerging as a strategic factor for the adaptation and innovation of companies in the clothing sector. Thus, the aim is to identify global trends and practices in I4.0 applications in the clothing sector based on a systematic literature review. From the systematic literature review, 11 articles were selected from the Scopus and Web of Science databases. The results showed global trends in the application of I4.0 enabling tools, such as the Internet of Things, Cybersecurity and Additive Manufacturing, in addition to the benefits that I4.0 can provide in manufacturing, such as the possibility of efficient processes with lower operating costs. When studying the perception of businesspeople, the most critical dimensions were: vertical integration, flexibility, data analysis, supply chain integration, traceability, remote production monitoring, strategy, organizational culture and people. The originality of the paper is highlighted by its specific sectoral focus, emerging applications of Industry 4.0 and holistic approach to the value chain. In addition to the academic contribution in terms of mapping key global trends, identifying challenges and opportunities and providing a basis for future research, the results can provide practical recommendations for companies in the apparel sector seeking to start or accelerate their digital transformation journey.