Analyzing the Clinical Efficacy of a Type 5 Phosphodiesterase Inhibitor Combined With Ziyin Baihuo Granules in the Treatment of Erectile Dysfunction

Abstract

The study explored the clinical efficacy of a type 5 phosphodiesterase inhibitor (PDE5i) combined with Ziyin Baihuo granules in the treatment of patients suffering from erectile dysfunction (ED) with yin deficiency and fire-hyperactivity syndrome. A total of 163 patients with erectile dysfunction were divided into observation and control groups. The observation group took tadalafil (Cialis) and Ziyin Baihuo granules orally, and the control group took only tadalafil orally, for 12 weeks. An additional 40 healthy people were selected as a normal group for comparison of the sex hormone levels before and after treatment of the participants in the erectile dysfunction group. After treatment, the symptoms of dry throat and tongue, tidal fever and night sweats, liking cold and avoiding heat, and waist pain showed significant improvement in the observation group ( p < .05). Compared with before treatment, the clinical indexes of erectile function in the control group and the observation group were improved after treatment ( p < .05). After treatment, Ziyin Baihuo granules combined with tadalafil restored the abnormal indexes of blood ( p < .05) in the observation group. Our research shows that PDE5i combined with Ziyin Baihuo granules could effectively improve erectile function.

Efficacy and safety assessment of traditional Chinese medicine for erectile dysfunction: A meta‐analysis and trial sequential analysis

“…The characteristics of enrolled trials are presented in Table 1. Among the included studies, a total of six studies compared TCM with placebo, 38–43 four studies compared TCM with PDE5Is, 44,45 17 studies focused on the effect of TCM as an add‐on to PDE5Is, 46–60 and 19 studies focused on the effect of TCM as add on to pharmaceuticals except for PDE5Is 61–79 . Besides, one study compared TCM with bromocriptine 80 .…”

“…Substantial improvement in clinical recovery rate by TCM was shown in Figure 4. Interestingly, the clinical recovery rates of Ding et al 45 (50.0%), Wang et al 56 (67.7%), Xu et al 48 (52.2%), Ye et al 58 (63.8%), Zhang et al 49 (82.1%), and Zhou et al 44 (57.1%) were relatively higher. Zhou et al conducted a head-to-head trial based on the treatment of chronic prostatitis, while the other five trials applied add-on therapy with PDE5Is.…”

“…Among the included studies, a total of six studies compared TCM with placebo, [38][39][40][41][42][43] four studies compared TCM with PDE5Is, 44,45 17 studies focused on the effect of TCM as an add-on to PDE5Is, [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] and 19 studies focused on the effect of TCM as add on to pharmaceuticals except for PDE5Is. [61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79] Besides, one study compared TCM with bromocriptine.…”