Analyzing the Effect of Weak External Transcranial Magnetic Stimulation on the Primary Dominant Frequencies of Alzheimer Patients Brain by Using MEG Recordings

Abstract

Backround and Objectives: Alternative, non-invasive, and non-pharmaceutical options are gaining place in the battle of Alzheimer’s Disease treatment control. Lately, the magnetic stimulation of the brain is the most prevalent technique with encouraging results. The aim of this study is to establish any possible change on the Primary Dominant Frequencies (PDF) (range 2–7 Hz) of the affected brain regions in Alzheimer Disease (AD) patients after applying extremely weak Transcranial Magnetic Stimulation. Materials and Methods: For this purpose, all AD patients were scanned with the use of MagnetoEncephaloGraphy (MEG) recordings through a whole-head 122–channel MEG system. Results: Our results exerted statistically significant PDF changes due to weak TMS accompanied by rabid attenuation of clinical symptoms. Conclusion: Thus, this is the first time that a positive therapeutic effect is being demonstrated even at pico-Tesla range magnetic fields in a small clinical group of studies for AD.

Possible influence on the Thymus Gland role to neutralize any foreign organisms acting on human brain subjects through Pineal Gland normal function and melatonin hormone synthesis

“…We also had the approval of the Research Committee of our University to record with the magnetoencephalogam (MEG) on these patients, using SQUID technology. [4][5][6][7][8] The procedure in all these patients using the pT-TMS and repeated MEG recording before and after the application of the (pT-TMS), as we have thoroughly reported in few of our publications, [4][5][6][7][8] have shown a positively statistically significant effect since 7 out 10 patients declared substantial clinical improvement and rapid attenuation to their symptoms. Our goal for this specified effect we have use the pT-TMS electronic device 9 after applying (Fast Fourier Tranform) FFT analysis.…”

“…This device produces a square wave format equivalent to the neuron's interaction or communication in the brain. [4][5][6][7][8] For the acquisition we have developed a software program in our all publications in order to score the Primary Dominant Frequencies (PDF) of the power spectra of the MEG obtained from all patients affected brain regions prior and following the weak TMS. The PDF for each signal was detected after applying FFT.…”

“…The PDF for each signal was detected after applying FFT. As is explained in our publications [4][5][6][7][8] there is a 7s duration MEG segment in each patient with the corresponding amplitude spectrum which is derived following the FFT analysis. Following the analysis of the PDF we have constructed two-dimentional color maps for the spatial distribution of the primary dominant frequencies based on these frequencies estimation for each affected brain region and channel in the constructed map.…”

“…Statistical analysis using unpaired Students's t-test and values p<0.05 of repeated MEG recording data from the human patients with various brain disorders before and after the (pT-TMS)Transcranial Magnetic Stimulation showed a positively statistically effect in the range of 60-75%. [4][5][6][7][8] In addition from the above was found that the proper function of the decalcified PG and particularly the TG was help to overcome any brain disorder and foreign organisms acting on the humam brain. They also reported significant clinical improvement on their symptomalology.…”

“…Even so, a sensible method could be that extremely low magnetic fields trigger inner pathways and neurotransmission nets of PG with different brain centers, via melatonin, to act as buffers over any possible neurologiacal disorder. 4 Moreover, this kind of magnetic stimulation can probably affect the PG-TG pathway, by normalizing PG activity, which is significantly impaired when being calcified, resulting in a potent immune system response over any abnormality. 11…”