Analyzing the impact of CFP1 mutational landscape on epigenetic signaling

Yang, Yidai; Yang, Yaqing; Chan, Kin; Couture, Jean-François

doi:10.1096/fj.202100427r

Cited by 10 publications

(8 citation statements)

References 107 publications

(214 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When CFP1/SETD1 or MLL1/2 binds to DNA, they hamper DNA methylation by blocking the access of DNMT3A 59 . CFP1 interacts with and recruits DNMT1 to suppress aberrant transcription re-initiation or silence specific genes 2 , 60 . The expression of Dnmt1 and Dnmt3a increased gradually in the mouse uterus during early pregnancy 61 .…”

Section: Discussionmentioning

confidence: 99%

“…CXXC finger protein 1 (CFP1) is an important player in the epigenetic regulation of genes by inducing trimethylation at histone H3 lysine 4 (H3K4me3) with SETD1, a histone methyltransferase 1 . H3K4me3 is mainly found in active promoters and turns chromatin into transcriptionally active euchromatin in the transcription start site (TSS) and CpG island (CGI) 2 . When CFP1 binds to unmethylated CpG, it recruits SETD1A/B to trigger H3K4me3 in the promoters of target genes to increase gene expression 1 , 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the conditional deletion of CFP1 highlighted that CFP1-associated H3K4me3 has fundamental roles in various biological processes. CFP1-deficient embryonic stem cells failed to differentiate in vitro because of aberrant H3K4me3 at non-methylated CGI promoters, leading to transcriptional disturbance 2 , 4 , 6 . CFP1 plays an important role in intrathymic T-cell development and differentiation program of TH17 cells 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis

et al. 2023

View full text Add to dashboard Cite

Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the underlying epigenetic cause remains unclear. Here we demonstrate that CFP1, a regulator of H3K4me3, is required for maintaining epigenetic landscapes of P4-progesterone receptor (PGR) signaling networks in the mouse uterus. Cfp1f/f;Pgr-Cre (Cfp1d/d) mice showed impaired P4 responses, leading to complete failure of embryo implantation. mRNA and chromatin immunoprecipitation sequencing analyses showed that CFP1 regulates uterine mRNA profiles not only in H3K4me3-dependent but also in H3K4me3-independent manners. CFP1 directly regulates important P4 response genes, including Gata2, Sox17, and Ihh, which activate smoothened signaling pathway in the uterus. In a mouse model of endometriosis, Cfp1d/d ectopic lesions showed P4 resistance, which was rescued by a smoothened agonist. In human endometriosis, CFP1 was significantly downregulated, and expression levels between CFP1 and these P4 targets are positively related regardless of PGR levels. In brief, our study provides that CFP1 intervenes in the P4-epigenome-transcriptome networks for uterine receptivity for embryo implantation and the pathogenesis of endometriosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…В своих работах мы сделали акцент на расширении интерактомной информации о мастер-регуляторе CFP1 (CxxC-finger protein-1, Uniprot ID: Q9P0U4) процессов эпигенетической регуляции генной экспрессии [55,56] как одном из наименее изученных CXXC-белков в контексте вовлечённости в неопластическую трансформацию клеток [57]. CFP1 кодируется геном CXXC1 18-ой хромосомы человека, что обуславливает также важность изучения его ББВ в рамках международного Проекта "Протеом Человека" (The Human Proteome Project, HPP).…”

Section: новые данные об интерактомике белка Cfp1unclassified

“…CFP1 кодируется геном CXXC1 18-ой хромосомы человека, что обуславливает также важность изучения его ББВ в рамках международного Проекта "Протеом Человека" (The Human Proteome Project, HPP). CFP1 является мультифункциональным и мультидоменным белком, влияющим на уровень метилирования ДНК и пост-трансляционные модификации гистоновых белков по типу метилирования и ацетилирования [56,58]. CFP1 связывается с открытым хроматином в области CpG-островков посредством домена "цинковые пальцы" [59].…”

Section: новые данные об интерактомике белка Cfp1unclassified

Interactomics of CXXC proteins involved in epigenetic regulation of gene expression

et al. 2022

View full text Add to dashboard Cite

Regulation of gene expression is an extremely complex and multicomponent biological phenomenon. Proteins containing the CXXC-domain “zinc fingers” (CXXC-proteins) are master regulators of expression of many genes and have conserved functions of methylation of DNA bases and histone proteins. CXXC proteins function as a part of multiprotein complexes, which indicates the fundamental importance of studying post-translational regulation through modulation of the protein-protein interaction spectrum (PPI) in both normal and pathological conditions. In this paper we discuss general aspects of the involvement of CXXC proteins and their protein partners in neoplastic processes, both from the literature data and our own studies. Special attention is paid to recent data on the particular interactomics of the CFP1 protein encoded by the CXXC1 gene located on the human chromosome 18. CFP1 is devoid of enzymatic activity and implements epigenetic regulation of expression through binding to chromatin and a certain spectrum of PPIs.

show abstract

Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes

Li,

Zhang,

Shen

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Cardiomyocyte maturation is the final stage of heart development, and abnormal cardiomyocyte maturation will lead to serious heart diseases. CXXC zinc finger protein 1 (Cfp1), a key epigenetic factor in multi‐lineage cell development, remains underexplored in its influence on cardiomyocyte maturation. This study investigates the role and mechanisms of Cfp1 in this context. Cardiomyocyte‐specific Cfp1 knockout (Cfp1‐cKO) mice died within 4 weeks of birth. Cardiomyocytes derived from Cfp1‐cKO mice showed an inhibited maturation phenotype, characterized by structural, metabolic, contractile, and cell cycle abnormalities. In contrast, cardiomyocyte‐specific Cfp1 transgenic (Cfp1‐TG) mice and human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) overexpressing Cfp1 displayed a more mature phenotype. Mechanistically, deficiency of Cfp1 led to a reduction in trimethylation on lysine 4 of histone H3 (H3K4me3) modification, accompanied by the formation of ectopic H3K4me3. Furthermore, Cfp1 deletion decreased the level of H3K4me3 modification in adult genes and increased the level of H3K4me3 modification in fetal genes. Collectively, Cfp1 modulates the expression of genes crucial to cardiomyocyte maturation by regulating histone H3K4me3 modification, thereby intricately influencing the maturation process. This study implicates Cfp1 as an important molecule regulating cardiomyocyte maturation, with its dysfunction strongly linked to cardiac disease.

show abstract

Analyzing the impact of CFP1 mutational landscape on epigenetic signaling

Cited by 10 publications

References 107 publications

CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis

CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis

Interactomics of CXXC proteins involved in epigenetic regulation of gene expression

Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes

Contact Info

Product

Resources

About