Waste heat recovery (WHR) from exhaust gases in natural gas engines improves the overall conversion efficiency. The organic Rankine cycle (ORC) has emerged as a promising technology to convert medium and low-grade waste heat into mechanical power and electricity. This paper presents the energy and exergy analyses of three ORC-WHR configurations that use a coupling thermal oil circuit. A simple ORC (SORC), an ORC with a recuperator (RORC), and an ORC with double-pressure (DORC) configuration are considered; cyclohexane, toluene, and acetone are simulated as ORC working fluids. Energy and exergy thermodynamic balances are employed to evaluate each configuration performance, while the available exhaust thermal energy variation under different engine loads is determined through an experimentally validated mathematical model. In addition, the effect of evaporating pressure on the net power output, thermal efficiency increase, specific fuel consumption, overall energy conversion efficiency, and exergy destruction is also investigated. The comparative analysis of natural gas engine performance indicators integrated with ORC configurations present evidence that RORC with toluene improves the operational performance by achieving a net power output of 146.25 kW, an overall conversion efficiency of 11.58%, an ORC thermal efficiency of 28.4%, and a specific fuel consumption reduction of 7.67% at a 1482 rpm engine speed, a 120.2 L/min natural gas flow, 1.784 lambda, and 1758.77 kW of mechanical engine power.Energies 2019, 12, 2378 2 of 22 and exergy efficiencies and minimizing exergy destruction [3]. Nevertheless, ORC-engine coupling must be carefully designed to avoid safety, performance, and revenue issues such as gas-fluid contact, as well as weight, complexity, and backpressure increase [4].ORC-WHR research has addressed the integration between ORC and combustion engines. Plenty of studies have established that ORC improves the overall conversion efficiency by increasing net power production without penalizing fuel consumption. Patel and Doyle [5] presented a first attempt for WHR from diesel engines by using ORC. Their ORC system achieved an overall power increase of 13% in a Mack 676 diesel vehicle engine without increasing fuel consumption. Peris et al. [6] simulated six ORC configurations for WHR from cooling water in internal combustion engines (ICE) by using 10 non-flammable fluids. Their study showed that ICE electric efficiency could be increased by 4.9-5.3%, by achieving overall conversion efficiencies up to 7.15% at a relatively low-temperature cooling water (90 • C). Yu et al.[7] simulated a diesel engine-ORC integration for WHR from the engine exhaust gases and cooling system by using R245fa as the ORC working fluid. Their results showed that 75% of exhaust gases energy and 9.5% of cooling water energy could be recovered if ORC operating conditions are optimized and controlled to maintain the power output. However, these results are limited to an exergetic analysis of a single ORC configuration. Lu et al. [8] ...