Analyzing the transition pressure and viscosity limit of a hydroelastic microfluidic oscillator

Xia, Huan; Wang, Z. P.; Nguyen, Van-Anh; Ng, Sum Huan; Wang, W.; Leong, Fong Yew; Le, Duc Vinh

doi:10.1063/1.4861778

Cited by 23 publications

(27 citation statements)

References 15 publications

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“…The system becomes unstable, and the diaphragm starts to vibrate up and down, converting the steady laminar flow to oscillatory flow. For more detailed discussion, please refer to Xia et al (2012Xia et al ( , 2014. The dimensions of current device are as follows: the diameter and depth of the main circular chamber: D mc = 4 mm, d mc = 150 µm.…”

Section: Mixer Device and Flow Controlmentioning

confidence: 99%

“…The microfluidic oscillator mixer using a spring metal diaphragm (Xia et al 2014) was tailored for current application. As illustrated in Fig.…”

Section: Mixer Device and Flow Controlmentioning

confidence: 99%

“…The device contains an elastomer diaphragm which, above a critical pumping pressure, will vibrate spontaneously converting the otherwise laminar flow to oscillatory flow. In a recent study (Xia et al 2014), the design was further improved using a more robust spring metal material to replace the elastomer. Since the device produces high-frequency oscillatory flow, rapid fluid mixing can be achieved.…”

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confidence: 99%

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Anti-solvent precipitation of solid lipid nanoparticles using a microfluidic oscillator mixer

Xia

Seah

Liu

et al. 2014

Microfluid Nanofluid

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cosmetic and pharmaceutical applications. For dermatological applications, they provide many advantages such as enhanced chemical stability, increased skin hydration effect, and prolonged release (e.g., of perfumes, insect repellents). Cosmetic products containing lipid nanoparticles are already available in the market (Müller et al. 2007;Pardeike et al. 2009). SLN are also an attractive option when used as a drug carrier. It may overcome the problems such as insufficient concentration and poor drug solubility. Advantages also include low toxicity, increased drug stability, high drug load, and precise release control. (Mehnert and Mäder 2001;Almeida and Souto 2007;Belliveau et al. 2012).SLN can be produced through high-pressure homogenization. In this method, the lipid is pushed by high pressure through a narrow gap and accelerated to a high velocity. Large shear stress and cavitation forces will be produced that break the lipid into nanoparticles. This process is energy intensive as the required pressure is up to several hundred bars or even higher. SLN are also prepared by precipitation. The lipid is first dissolved in a solvent. Then, upon either evaporation of the solvent or addition of an anti-solvent, a nanoparticle dispersion will be formed by precipitation of the lipid (Sjöström and Bergenståhl 1992;Dong et al. 2012). Other methods include microemulsion, higher shear homogenization, and ultrasound. More detailed discussion can be found in Mehnert and Mäder (2001).The property of SLN is largely influenced by the size, uniformity, and morphology. Usually, smaller and more uniform SLN are preferred for higher stability, better absorption, and precise release control. In the precipitation synthesis method, one important factor that influences the quality of SLN is the mixing process. The mixing time need to be less than the precipitation time. Otherwise, slow and incomplete mixing will lead to large and wide Abstract The mixing process is critical in the anti-solvent precipitation process of micro-/nanoparticles. It may directly determine the quality of particles, especially the size and uniformity. In this study, a previously developed microfluidic oscillator mixer is used for anti-solvent precipitation of solid lipid (Gelucire 44/14) nanoparticles. This micromixer generates high-frequency oscillatory flow to enhance the fluid mixing. Based on the design, high flow rates of up to 50 ml/min can be achieved to allow relatively high throughput production. Results show that, within a wide concentration range from 10 to 300 mg/ml, solid lipid particles of 50-240 nm can be produced with the polydispersity index ranging from around 0.16 to 0.26. The influences of the anti-solvent to solution flow rate ratio, the geometrical and operating parameters of the oscillator mixer including the secondary chamber depth, and pumping pressure are investigated. For comparison, the same process was also conducted using a static chaotic mixer. Relevant findings provide useful reference for the performance and potential applicatio...

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Section: Mixer Device and Flow Controlmentioning

confidence: 99%

“…The microfluidic oscillator mixer using a spring metal diaphragm (Xia et al 2014) was tailored for current application. As illustrated in Fig.…”

Section: Mixer Device and Flow Controlmentioning

confidence: 99%

mentioning

confidence: 99%

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Anti-solvent precipitation of solid lipid nanoparticles using a microfluidic oscillator mixer

Xia

Seah

Liu

et al. 2014

Microfluid Nanofluid

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“…In technology, the realization of chemical oscillators is challenging, in contrast to electronic oscillators. Recently, the construction of microfluidic oscillators has been demonstrated . However, these oscillators operate on purely mechanical principles with no influence of the chemical domain on the fluidic domain.…”

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Autonomous Chemical Oscillator Circuit Based on Bidirectional Chemical‐Microfluidic Coupling

Paschew

Schreiter

Voigt

et al. 2016

Adv Materials Technologies

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A chemofluidic oscillator circuit that employs a hydrogel‐based chemofluidic transistor for chemical‐fluidic coupling is presented. It shows a period between 200 and 1000 s and alcohol concentrations oscillating between 2 wt% and 10 wt%. Because of the direct interaction with chemistry, chemofluidic transistors have the potential to facilitate labs‐on‐chips with enhanced functionality and scalability.

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“…Known strategies to realize droplet formation or oscillatory flow in microfluidics include squeeze-off in flowfocusing devices (Gupta et al 2014), oscillatory switching with compliant diaphragms (Mosadegh et al 2010;Xia et al 2010) or pneumatics (Nguyen et al 2012) or the use of external capacitance to realize an oscillator with a remarkable kinetic tuning range (Kim et al 2013). One of the technologically most advanced examples is a collection of digital fluid logics, NAND and NOR gates, that can be cascaded into a logic oscillator (Devaraju and Unger 2012).…”

Section: Introductionmentioning

confidence: 99%

Biphasic fluid oscillator with coaxial injection and upstream mass and momentum transfer

Heuberger

Gottardo

Dressler

et al. 2015

Microfluid Nanofluid

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Analyzing the transition pressure and viscosity limit of a hydroelastic microfluidic oscillator

Cited by 23 publications

References 15 publications

Anti-solvent precipitation of solid lipid nanoparticles using a microfluidic oscillator mixer

Anti-solvent precipitation of solid lipid nanoparticles using a microfluidic oscillator mixer

Autonomous Chemical Oscillator Circuit Based on Bidirectional Chemical‐Microfluidic Coupling

Biphasic fluid oscillator with coaxial injection and upstream mass and momentum transfer

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