In this analysis, the expected objective is to determine the influence of Education, Gross Regional Domestic Product, District Minimum Wage, and Population on the Open Unemployment Rate of Central Java Province in 35 Regencies/Cities in Central Java Province in 2020-2021. This study used the panel data method. The model which selected is Fixed Effect Model (FEM). Based on the regression of this study shows that the variables of Education, Population Numbers have a large and favorable impact on the open unemployment rate. The District Minimum Wage variable turned out to effected negative and significant. Meanwhile, the variable Gross Regional Domestic Product has a positive and insignificant effect. Based on the simultaneous test of Education, the District Minimum Wage and Population Amount were significant at 93.84% and the remaining 6.16% was impacted by variables other than those considered in the model.