Anaphylactic Reaction to Omeprazole

Stefanaki, E.; Vovolis, V.; Letsa, Ioanna; Koutsostathis, Nikolaos

doi:10.1111/j.1572-0241.2008.01851.x

Cited by 2 publications

(5 citation statements)

References 18 publications

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“…It has been proposed that basophil activation test (BAT) might help in the diagnosis of IgE-mediated allergic reactions to PPIs in two case reports [77,82].…”

Section: Diagnostic Proceduresmentioning

confidence: 99%

“…According to the published articles, it is possible to identify four different patterns of cross-reactivity among PPIs: & Whole group hypersensitivity: patients with allergy to all PPIs [49,52,54,77]. & Pattern A: patients with allergy to omeprazole, esomeprazole and pantoprazole but tolerating lansoprazole and rabeprazole [45,47,48,82].…”

Section: Cross-reactivity Among Ppismentioning

confidence: 99%

“…& Pattern C: patients with selective sensitization to a single PPI and who tolerate other PPIs [53,76,77,79,84].…”

Section: Cross-reactivity Among Ppismentioning

confidence: 99%

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Hypersensitivity Reactions to Proton Pump Inhibitors

Lombardo

Bonadonna

2015

Curr Treat Options Allergy

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Proton pump inhibitors I Drug allergy I Anaphylaxis I Adverse drug reaction I Drug hypersensitivity Opinion Statement Proton pump inhibitors (PPIs) are drugs widely used and usually well tolerated. However, cases of immediate or cell-mediated hypersensitivity reactions due to all PPIs, with the exception of the newest dexlansoprazole and tenatoprazole, have been described. In the case of suspected IgE-mediated reaction skin test (prick test and intradermal test) with nonirritant drug concentration published is safe and highly specific (100 %) with a PPV of 100 %. Thus, oral provocation test should be performed only in case of negative results to rule out definitely the diagnosis. In the case of possible cell-mediated hypersensitivity reaction, a delayed reading of intradermal test, at least after 24 and 48 h, and patch test should be performed, but we do not have standardized procedures so far. Cross-reactivity among all PPIs is not a dogma, in fact, three patterns of cross-reactivity have been described. Thus, in patients with ascertained allergy to a PPI, a complete evaluation (skin test and oral provocation test) of all five PPIs available helps to identify a safe alternative.

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“…It has been proposed that basophil activation test (BAT) might help in the diagnosis of IgE-mediated allergic reactions to PPIs in two case reports [77,82].…”

Section: Diagnostic Proceduresmentioning

confidence: 99%

Section: Cross-reactivity Among Ppismentioning

confidence: 99%

See 1 more Smart Citation

Hypersensitivity Reactions to Proton Pump Inhibitors

Lombardo

Bonadonna

2015

Curr Treat Options Allergy

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“…Combinations of PPIs and antibiotics are often prescribed to eradicate Helicobacter pylori and to prevent gastropathy induced by non‐steroidal anti‐inflammatory drugs. To date, there have been several reports of type I hypersensitivity reactions to PPIs, which were urticaria, angioedema and anaphylaxis 1–4 . Here, we present two patients with anaphylaxis to PPIs, one each to lansoprazole and omeprazole.…”

Section: What Is Known and Objectivementioning

confidence: 90%

“…To date, there have been several reports of type I hypersensitivity reactions to PPIs, which were urticaria, angioedema and anaphylaxis. [1][2][3][4] Here, we present two patients with anaphylaxis to PPIs, one each to lansoprazole and omeprazole.…”

Section: What Is Known and Objectivementioning

confidence: 99%