Anaphylactic shock during elimination diets for severe atopic eczema.

David, T J

doi:10.1136/adc.59.10.983

Cited by 147 publications

(68 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this purpose the diet is gradually relaxed, including reintroduction of one food at a time. It should, however, be noted at this point that after avoiding a food for some time its reintroduction into the diet is not always safe and that anaphylactic reactions have been described [10]. (Fig.…”

Section: If the Clinician Relies On The Results Of Prick Tests Andmentioning

confidence: 97%

Recent advances in the pathogenesis of atopic dermatitis

Bever

1992

Eur J Pediatr

View full text Add to dashboard Cite

Atopic dermatitis (AD) is an inflammatory skin disorder affecting 5%-10% of children. Although basic mechanisms remain largely speculative, recent studies on the pathogenesis have elucidated new insights, pointing to the importance of food and inhalant allergens. The pathogenesis of AD can be more easily explained by the model of late skin reaction occurring after mast cell activation. The present report highlights some of the more recent developments in the mechanisms of AD which can be important in understanding and treating this troublesome disease.

show abstract

Section: If the Clinician Relies On The Results Of Prick Tests Andmentioning

confidence: 97%

Recent advances in the pathogenesis of atopic dermatitis

Bever

1992

Eur J Pediatr

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that soy proteins are less immunogenic and allergenic than CMP [35]; no fatal anaphylactic reactions have been triggered in animal models sensitized with soy proteins. Only a few cases of soy anaphylaxis have been reported in human subjects [36], and it appears to be a rare phenomenon [37]. In spite of this, some authors advise avoidance of soy-based formulas in infants, because it is as antigenic as CM formulas [13,38,39].…”

Section: Discussionmentioning

confidence: 99%

Detection and identification of a soy protein component that cross-reacts with caseins from cow's milk

Rozenfeld

Docena

Añón

et al. 2002

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Food allergy is becoming a medical, economical and social problem. Soybean, together with milk, peanuts and eggs, are the major allergenic foods. This pathology affects the infant population, when the gut barrier is immature and the immune system is still refining its ability to tolerate food proteins. In our country, cow's milk allergy (CMA) constitutes the main food allergy in infancy, but soy allergy has become exacerbated because of the increased utilization of soy-based formulas as cow's milk (CM) substitutes and the inclusion of soy-proteins in many processed foods. Once a food allergy is diagnosed, the only proven therapy is the strict elimination of the offending allergens from the diet. Available substitutes for CM include milks from different mammalian animals, soy-based formulas, hydrolysed cow's milk proteins (CMP) and amino acid-based formulas. Furthermore, there is evidence that soy proteins may trigger allergic reactions in CMA patients, as assessed by a double-blind placebo controlled food challenge (DBPCFC) [1].Milk contains more than 50 proteins and the major ones are implicated in a number of immunologically mediated reactions [2]. Caseins and b-lactoglobulin (b-Lg) have been described as the main antigenic and allergenic components for human beings [3,4], although immunoglobulins, a-lactalbumin (a-La), and bovine serum albumin (BSA) were also found to be reactive with different isotypes of human antibodies [5,6]. Several immunoreactive epitopes have been identified in caseins [7,. Most of the epitopes present in the casein molecules are sequential since the high number of proline and hydrophobic residues (45%) in these proteins determine an undefined secondary and tertiary structure [10]. Besides, caseins tend to aggregate as a result of hydrophobic interactions to give quaternary structures [11], and this may create conformational epitopes buried in the hydrophobic interior of the micelle [7]. These epitopes are only exposed and accessible to the immune system after denaturation of the complex by digestion.A number of soy proteins that bind antibodies, especially IgE, have been identified [12,13]. The main fractions of storage globulins from seed proteins are the complexes 7S or b-conglycinin, and 11S or glycinin. The 7S complex is generally a trimer with MW 150-200 kD, whereas 11S is a hexamer with MW 300-400 kD [14]. In the 7S fraction, or b-conglycinin, several IgE-binding proteins have been identified and some of them have been purified and characterized: Gly m Bd 28K, Gly m Bd 30K, Gly m Bd 60K [15,16]. Sequence homology has been reported between these allergens and the thiol proteinase family SUMMARYSoy-based formulas are the most employed cow's milk substitutes in the treatment of cow's milk allergy in our country. Since adverse reactions have been reported in allergic patients as a consequence of exposure to soy proteins, we have investigated the possible cross-reactivity between components from soybean and cow's milk. A cow's milk specific polyclonal antiserum and casein specific m...

show abstract

“…1,118 The onset of immediate hypersensitivity reactions upon food avoidance has been well documented in patients with eczema. [119][120][121] Last, the data on the effects of repeated anesthesia on growth and development in otherwise healthy children are limited, but the discovery and utilization of less invasive techniques for EoE management would have significant clinical impact. 122,123 …”

Section: Maintenance Therapymentioning

confidence: 97%

Eosinophilic Esophagitis

Aceves¹

2015

Immunology and Allergy Clinics of North America

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is a clinicopathologic disease of increasing prevalence. Because EoE is a chronic disease, its prevalence will continue to increase. Antigen triggers, including food and aeroallergens, drive eosinophilic and T helper cell type 2 inflammation, resulting in subepithelial fibrosis; this esophageal remodeling is the likely underlying pathogenesis for complications of narrowing, rigidity, and food impactions. Management includes dietary antigen elimination and topical corticosteroids. Long-term therapy and repeated endoscopy are often needed; consideration must be given to maintenance regimens and side effects. This review describes the clinical features, treatment options, epidemiology, and pathogenesis of EoE.

show abstract

Anaphylactic shock during elimination diets for severe atopic eczema.

Cited by 147 publications

References 12 publications

Recent advances in the pathogenesis of atopic dermatitis

Recent advances in the pathogenesis of atopic dermatitis

Detection and identification of a soy protein component that cross-reacts with caseins from cow's milk

Eosinophilic Esophagitis

Contact Info

Product

Resources

About