Anaphylactoid Purpura in Children (Schönlein-Henoch Syndrome)

Allen, Donald M.; Diamond, Louis K.; Howell, Doris A.

doi:10.1001/archpedi.1960.02070030835021

Cited by 354 publications

(126 citation statements)

References 25 publications

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“…Am J Dis Child 1964;108:67â€"72 are reported to be affected twice as often as girls, although in our series there was a slight female predominance. Systemic manifestations develop in 80% of patients and in most the skin is involved first [3,4]. The rash is initially urticarial, becomes maculopapular, and then petechial or purpuric, and has a predilection for the buttocks and lower extremities.…”

Section: Schonlein Syndromementioning

confidence: 99%

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Henoch-Schonlein syndrome in children: gastrointestinal manifestations

Glasier¹,

Siegel²,

McAlister³

et al. 1981

American Journal of Roentgenology

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Section: Schonlein Syndromementioning

confidence: 99%

“…Transient arthralgias occur in two-thirds of cases in adults, although the incidence is not known in children. In 14% of patients the rash may appear after the onset of gastrointestinal symptoms [4]. In these patients the abdominal findings may mimic those of a surgical abdomen [6] (case 1).…”

Section: Schonlein Syndromementioning

confidence: 99%

Henoch-Schonlein syndrome in children: gastrointestinal manifestations

Glasier¹,

Siegel²,

McAlister³

et al. 1981

American Journal of Roentgenology

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“…The latter disorder is also more commonly observed in males and is frequently preceeded by a viral infection (7). The mechanism(s) responsible for the deposition of IgA in these disorders is unclear.…”

Section: Introductionmentioning

confidence: 99%

Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus.

Conley¹,

Cooper²,

Michael³

1980

J. Clin. Invest.

302

138

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“…The disease often begins after an upper respiratory tract infection. The presence of palpable purpura is essential to the diagnosis, abdominal pain and arthalgia or arthritis usually occur only in 80% of the cases, and glomerulonephritis develops in~20±50% of the children [5,6].Clinically important pulmonary disease is extremely rare in this condition [7±10]. The cases reported in the literature were fatal and post mortem examination revealed pulmonary haemorrhage or infarction secondary to vasculitis.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Pulmonary function abnormalities in children with Henoch-Schonlein purpura

Cazzato

Bernardi²,

Cinti³

et al. 1999

Eur Respir J

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Henoch±Scho Ènlein purpura (HSP) is a widespread necrotizing vasculitis affecting small vessels characterized by nonthrombocytopenic purpura. Pulmonary involvement is a rare fatal complication with diffuse alveolar haemorrhage. The objective of this study was to evaluate possible early lung function abnormalities and to establish any relationship with the clinical activity of the disease.Fifteen children with HSP and without clinical or radiological evidence of lung involvement underwent pulmonary function study at the onset of the disease. A sample of 28 subjects matched by age, height, and weight was chosen as a control group. After a mean of 21 months (range 12±43) lung function tests were repeated in 10 of the previously studied children.During the acute phase of the disease the transfer factor for carbon monoxide, measured by steady-state (TL,COss) and single-breath (TL,COsb) methods, was found to be significantly lower in children with HSP than control subjects. There was no significant relationship between pulmonary function tests with symptoms and signs at onset, nor was there any correlation between variables and serum immunoglobulin A (IgA) concentration. In all but two patients, clinical recovery was observed within 6 weeks from the onset of the disease. In one case relapses of purpuric skin lesions were observed during the first 3 months of follow-up. The second case had relapses of purpuric skin lesions and microscopical haematuria during the 12 months following the onset of the disease with characteristic IgA mesangial deposition on renal biopsy. Although the overall mean value of TL,COsb improved from baseline to the second investigation, in both patients the recurrences of clinical signs were associated with a slight impairment of TL,COsb at the second evaluation.These data suggest an early subclinical lung impairment in children with Henoch± Scho Ènlein purpura during the active phase of the disease. The presence of isolated pulmonary function abnormalities was not associated with the subsequent development of lung disease. Eur Respir J 1999; 13: 597±601. Henoch±Scho Ènlein purpura (HSP) is a widespread necrotizing vasculitis affecting small vessels characterized by nonthrombocytopenic purpura. The histopathological features show leukocytoclastic vasculitis with infiltration of the necrotic vessel wall by leukocytes, and scattered nuclear debris accumulates around the lesions [1]. It is primarily a childhood disorder and occurs mostly between 5 and 15 yrs of age [2±4]. The disease often begins after an upper respiratory tract infection. The presence of palpable purpura is essential to the diagnosis, abdominal pain and arthalgia or arthritis usually occur only in 80% of the cases, and glomerulonephritis develops in~20±50% of the children [5,6].Clinically important pulmonary disease is extremely rare in this condition [7±10]. The cases reported in the literature were fatal and post mortem examination revealed pulmonary haemorrhage or infarction secondary to vasculitis. The transfer facto...

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Anaphylactoid Purpura in Children (Schönlein-Henoch Syndrome)

Cited by 354 publications

References 25 publications

Henoch-Schonlein syndrome in children: gastrointestinal manifestations

Henoch-Schonlein syndrome in children: gastrointestinal manifestations

Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus.

Pulmonary function abnormalities in children with Henoch-Schonlein purpura

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